IndraLab

Statements

KCNJ inhibits KCNMA1. 11 / 11
| 9 2
reach
"In both native parotid acinar cells and in a heterologous expression system, activation of IK1 channels inhibits maxi-K activity."
16418402
sparser
"While there are similarities between the inactivation of BK channels by their β subunits and the IK1-induced BK channel inhibition, there are at least a couple of differences."
19574736
reach
"Thus, we conclude that IK1 activation produced a mostly voltage independent reduction of the BK channel open probability."
19574736
reach
"A quantitative prediction of this competition can be made by considering that the BK channel can be inhibited by IK1 activation or by the peptide in a mutually exclusive manor."
19574736
sparser
"The relationship among the probabilities of finding the BK channel in one of its three states is:where P IK • BK is the probability that the BK channel is inhibited by IK1."
19574736
reach
"The relationship among the probabilities of finding the BK channel in one of its three states is : PBK+PNP * BK+PIK * BK = 1 where PIK * BK is the probability that the BK channel is inhibited by IK1."
19574736
reach
"Activation of IK1 channels decreased the activity of maxi-K channel in cells having normal levels of cholesterol."
25804641
reach
"As noted in Introduction, activation of the Ca 2+ -dependent K channel, IK1, in mouse parotid acinar (and other) cells inhibits another type of Ca 2+ -sensitive K channel, the large conductance, BK channel."
19574736
reach
"Thus, the chemical activation of IK1 channels in cell-free membrane patches significantly inhibited maxi-K channel activity."
16418402
reach
"While there are similarities between the inactivation of BK channels by their beta subunits and the IK1 induced BK channel inhibition, there are at least a couple of differences."
19574736
reach
"The overarching assumption in this model is that the ability of the IK1 N-terminus to inhibit the BK channel is directly related to the IK1 channel open probability."
19574736