IndraLab

Statements

KCNJ inhibits KCNMA1. 12 / 12
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"Taken together, Cys thiol modifying agents such as DTNB and MTSEA inhibit the BK current (DiChiara and Reinhart, 1997; Soh et al., 2001; Soto et al., 2002; Tang et al., 2001; Wang et al., 1997b), suggesting that oxidative modification of Cys residues in the BK channel promotes inhibition of BK channel function."
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"Activation of IK1 channels decreased the activity of maxi-K channel in cells having normal levels of cholesterol."
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"The overarching assumption in this model is that the ability of the IK1 N-terminus to inhibit the BK channel is directly related to the IK1 channel open probability."
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"While there are similarities between the inactivation of BK channels by their beta subunits and the IK1 induced BK channel inhibition, there are at least a couple of differences."
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"In both native parotid acinar cells and in a heterologous expression system, activation of IK1 channels inhibits maxi-K activity."
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"A quantitative prediction of this competition can be made by considering that the BK channel can be inhibited by IK1 activation or by the peptide in a mutually exclusive manor."
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"The relationship among the probabilities of finding the BK channel in one of its three states is : PBK+PNP * BK+PIK * BK = 1 where PIK * BK is the probability that the BK channel is inhibited by IK1."
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"The relationship among the probabilities of finding the BK channel in one of its three states is:where P IK • BK is the probability that the BK channel is inhibited by IK1."
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"While there are similarities between the inactivation of BK channels by their β subunits and the IK1-induced BK channel inhibition, there are at least a couple of differences."
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"Thus, the chemical activation of IK1 channels in cell-free membrane patches significantly inhibited maxi-K channel activity."
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"Thus, we conclude that IK1 activation produced a mostly voltage independent reduction of the BK channel open probability."
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"As noted in Introduction, activation of the Ca 2+ -dependent K channel, IK1, in mouse parotid acinar (and other) cells inhibits another type of Ca 2+ -sensitive K channel, the large conductance, BK channel."
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