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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Propofol activates HCN1. 2 / 2

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"Cacheaux et al. found that clinically relevant concentrations of propofol inhibited I or slowed activation kinetics of HCN1, HCN2, and HCN4 in heterologous cells, with the greatest effect on HCN1 (Cacheaux et al., 2005)."

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"In addition, hypnotic sensitivity to two other intravenous anesthetics in HCN1 knockout mice matched effects on HCN1 channels; propofol selectively inhibited HCN1 channels and propofol sensitivity was diminished in HCN1 knockout mice whereas etomidate had no effect on HCN1 channels and hypnotic sensitivity to etomidate was unaffected by HCN1 gene deletion."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...