IndraLab

Statements

Modified CTNNB1 activates CTNNB1. 4 / 4
| 4
reach
"In the presence of WNT ligands, the beta-catenin destruction complex does not form, beta-catenin escapes ubiquitin-proteasome degradation and translocates to the nucleus to enable transcription of WNT and beta-catenin target genes."
29316982
reach
"Although beta-catenin expression rescues Dnmt1 expression in CTNNB1 KO -HCT116 cells, we did not observe rescue of beta-catenin protein levels in DNMT1 KO -HCT116 cells following expression of Dnmt1 (XREF_FIG)."
25753001
reach
"Mutations at APC occur early in CRC and result in increased beta-catenin levels which lead to the expression of Wnt and beta-catenin responsive genes."
24931005
reach
"As shown clearly in the Western analysis of these cells, re-expression of beta-catenin rescues Dnmt1 protein expression in the CTNNB1 -/- cells, indicating the dependence of Dnmt1 protein levels on beta-catenin, although in the reciprocal experiment (XREF_FIG) in which Dnmt1 was expressed in DNMT1 KO -HCT116 cells, significant restoration of beta-catenin protein levels was not observed."
25753001