IndraLab

Statements

TNFAIP3 inhibits inflammatory response. 35 / 38
| 11 19 5
eidos
"A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis The pathophysiology of periodontal disease involves a perturbed immune system to a dysbiotic microflora leading to unrestrained inflammation , collateral tissue damage , and various systemic complications ."
32218782
eidos
"In vivo and in vitro experiments indicated that inflammation , a key characteristic of epilepsy , was inhibited by TNFAIP3 upregulation , as evidenced by the downregulated expression of pro-inflammatory cytokine interleukin ( IL ) -1 beta and inducible NO synthase ( iNOS ) , along with the decreased levels of NLRP3 inflammasome , which could activate inflammation ."
36454111
eidos
"Similarly , deficiency in CYLD or A20 , a master regulator of NFkappaB , lead to overt pathway activation and inflammation ( 132 ) ."
33324551
sparser
"Taken together, A20 inhibited FFAs-induced inflammatory response via attenuating NF-κB activation in four cell lines we generated."
26681923
reach
"TNFAIP3 is primarily responsible for attenuation of NFkappaB signaling and thereby inhibits inflammation and tumorigenesis and TNF mediated mediated apoptosis [XREF_BIBR]."
26049759
reach
"In vivo and in vitro experiments indicated that inflammation, a key characteristic of epilepsy, was inhibited by TNFAIP3 upregulation, as evidenced by the downregulated expression of pro-inflammatory cytokine interleukin (IL)-1β and inducible NO synthase (iNOS), along with the decreased levels of NLRP3 inflammasome, which could activate inflammation."
36454111
reach
"Additionally, the same group has reported that TNFAIP3 can endogenously suppress ASK1 and reduce apoptosis, lipid accumulation, and inflammation [XREF_BIBR]."
33353156
reach
"Tnfaip3 expression is necessary for prevention of chronic inflammation and autoimmune pathology according to studies on mice with full or conditional gene deletion [XREF_BIBR]."
25563673
reach
"Collectively, we infer that TNFAIP3 relieves neuronal injury in epilepsy by suppressing inflammation."
36454111
reach
"TNFAIP3 is an inhibitor of TNF-alpha inflammatory response via NF-kappaB and protects cells from TNF induced apoptosis, through inhibition of the caspase cascade and by prevents endothelial cell activation XREF_BIBR."
24587287
reach
"TNFAIP3 is particularly important to maintain homeostatic NFkappaB activation and suppress inflammation in the intestinal milieu where mucosal surfaces are constantly exposed to luminal bacteria."
28842689
sparser
"Altogether, A20 inhibited NF-κB-mediated inflammatory response without influencing or even could be taken as the mediator of its hepatoprotective function xref , xref , xref , xref ."
26681923
reach
"TNFAIP3 inhibited inflammatory response and enhanced autophagy, thereby alleviating PD in mice."
37019273
sparser
"Given the fact that A20 can inhibit inflammation, and as TNF-α-associated intestinal inflammation is a pivotal factor in IBD pathogenesis, we explored the correlation between TNF-α production, A20 expression, and disease status."
29881302
reach
"A panel of 10 inflammatory cytokines and expression of TNFAIP3 (A20; inhibits NF-kappabeta-induced inflammation) were analyzed in duodenal and ileal biopsies."
26933801
eidos
"In COPD airway epithelium , influenza virus infection increased microRNA-125a / b , which directly inhibits A20 and mitochondrial antiviral-signaling protein ( MAVS ) to promote inflammation and impair antiviral responses in COPD ( 84 ) ."
32655557
reach
"A previous study suggested that TNFAIP3 could prevent ICH caused damaging inflammation of the brain."
34163322
eidos
"Given the greater repression of inflammation by A20 compared to ABIN1 , we sought to understand whether keratinocytes in psoriasis and other rashes display upregulation of the A20 repressed gene sets discovered in our NHEK experiments ."
30543901
eidos
"Cell type specific roles for TNFAIP3 in intestinal inflammation have been demonstrated by lineage specific deletions showing that TNFAIP3 mainly suppresses inflammation in myeloid cells , while it mainly suppresses cell death in intestinal epithelial cells ( IEC ) 11 ."
29988117
eidos
"Numerous researchers have identified that A20 is a susceptibility gene for inflammatory diseases , and that A20 inhibits inflammation by regulating the NF-kappaB pathway.17-21 Interestingly , when NF-kappaB translocates into the nucleus and binds to the kappaB binding site in the A20 gene promoter structure , it can promote the expression of the A20 gene , and A20 acts as an ubiquitinating enzyme to modify the upstream molecules of the NF-kappaB pathway , leading to a negative feedback loop between A20 and the NF-kappaB ."
32566144
reach
"axis likely plays a role in SARS-CoV-2 infection as well, with TNFAIP3 inhibiting NF-κB-mediated antiviral responses at the site of local infection yet promoting a systemic inflammatory response in the periphery."
| DOI
eidos
"Results demonstrated that TNFAIP3 knockdown contributed to the proliferation ( Fig. 5b ) , migration ( Fig. 5d ) , invasion ( Fig. 5e ) , and inflammation ( Fig. 5f ) and suppressed the apoptosis ( Fig. 5c ) in HAND2-AS1-overexpressed MH7A cells ."
33549125
eidos
"One mechanism by which A20 inhibits inflammation is through negative regulation of NLRP3 and caspase-1 activation , suppressing interleukin production and pyroptosis ( 167 , 168 ) ."
33995417
reach
"TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation."
35464428
eidos
"Thus , BRO might prevent excessive inflammation also by upregulation of TNFAIP3 ."
31067687
reach
"A variant of TNFAIP 3, which encodes an ubiquitin editing enzyme inhibiting NF-kappaB-dependent signaling and prevents inflammation, and polymorphic haplotypes of the human T-lymphotropic virus-1-related endogenous sequence (HRES) 1 long terminal repeat (LTR) have been associated with SLE [XREF_BIBR, XREF_BIBR]."
22110541
eidos
"TNFAIP3 inhibited inflammatory response and enhanced autophagy , thereby alleviating PD in mice ."
37019273
reach
"TNFAIP3 inhibits inflammatory response and promotes extracellular matrix expression in human NPCs."
33226960
reach
"Furthermore, TNFAIP3 is activated by NF-kappaB in response to pro inflammatory signals such as TNF-alpha and can inhibit inflammation and programmed cell death."
29214018
reach
"TNFAIP3 is involved in the cellular response to H O and negatively regulates B cell activation, the CD40 signaling pathway, inflammatory response, and the death domain receptor exogenous apoptosis signaling pathway [41,42,43,44]."
31703342
reach
"In summary, overexpressed TNFAIP3 can promote autophagy and reduce inflammation in LPS induced human NPCs."
33226960
sparser
"A20 has been implicated in negatively regulating NF-κB signalling, cell death and inflammasome activation; however, the mechanisms by which A20 inhibits inflammation in vivo remain poorly understood."
31086261
sparser
"These results supported that A20 could inhibit the inflammatory response via regulating NF-κB activation in hepatic injury models in vitro ."
28473659
reach
"The results of this study showed that TNFAIP3 significantly reduces inflammatory response and ameliorates the degradation of the extracellular matrix by promoting autophagy in LPS-induced-inflammatory human NPCs that mimics IVDD."
33226960
reach
"TNFAIP3 has been found to limit inflammation and perform as an apoptosis mediator."
22127930