IndraLab

Statements


| 5

reach
"POH1 interacts with pro-IL-1beta."

reach
"We immunoprecipitated POH1 from BMDMs pretreated with LPS, and found that POH1 could interact with pro-IL-1beta, pro-caspase-1 and NLRP3."

reach
"Collectively, these results show that POH1 interacts with pro-IL-1beta prior to inflammasome activation."

reach
"Intrigued by the physical interaction that occurs between POH1 and pro-IL-1beta, we first sought to examine whether POH1 regulates pro-IL-1beta ubiquitination."

reach
"Of note, the interaction between POH1 and pro-IL-1beta did not require the presence of the inflammasome agonists."