IndraLab

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CDK4 phosphorylates NPM1. 4 / 4
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"Our recent work showed that NPM is phosphorylated by Cdk4 during the G1 phase, and that expressing NPM T199A , a mutant lacking the Cdk2/Cdk4 phosphorylation site prevented CA in p53-null cells ( xref )."
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"Cdk2 and Cdk4 were proposed to promote centriole reduplication in mouse fibroblasts by hyperphosphorylating the centrosomal protein nucleophosmin, a putative inhibitor of centriole duplication."
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"For example, the Wnt signaling pathway inhibits FOXM1 degradation, while direct interaction with NPM and direct phosphorylation by Cdk4,6/cyclinD complexes stabilize FOXM1 protein."
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"Hyperphosphorylation of NPM at T199 was accompanied by centrosome amplification and the appearance of multipolar spindles [XREF_BIBR], making a case for Cdk4 mediation of NPM phosphorylation."
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