IndraLab

Statements

CYLD phosphorylates RIPK3. 2 / 2

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"CYLD deficiency led to hyper-ubiquitinated RIP1 in the necrosome and impaired phosphorylation of RIP1 and RIP3."

24098568

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reach

"Upon TNF stimulation, CYLD can trigger necroptosis by promoting necrosome formation, phosphorylation and activation of RIPK3 51, but caspase-8 can cleave CYLD to suppress necroptosis 50."

29371616

INDRA sources:

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IndraLab

Statements

CYLD phosphorylates RIPK3. 2 / 2

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