IndraLab

Statements

Methyltransferase activity methylates TP53 on K372. 3 / 3
| 3
sparser
"In particular, methylation of p53 by SET7/9 methyltransferase on K372 results in p53 stabilization and increased p21 expression ( xref )."
28073943
sparser
"It has recently been shown that p53 can be methylated at K372 by Set9 methyltransferase,[ xref ] and that the PHD finger of ING1/2 is required for p53 activity.[ xref , xref , xref ] Addition of the p53K372me3 or p53K372me1 peptides resulted in small chemical shift changes in the ING2 (and homologous ING1) PHD finger, however the binding was at least tenfold weaker than the interaction with unmodified H3."
19184981
sparser
"Among these enzymes is Set9, a histone methyltransferase, which efficiently methylates p53 and E2F1 at Lys 372 and Lys 185 , respectively, with opposite consequences on their respective activities xref , xref ."
23251702