IndraLab
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reach
"2) Developmental dysregulation of cortical and/or thalamic HCN channel expression may contribute to epileptogenesis in genetic models of absence epilepsy : In two models, the Wistar Albino Glaxo and Rijswijk (WAG and Rij) and the Genetic Absence Epileptic Rats of Strasbourg (GAERS), the relative contribution of HCN1 channels to the channel pool and thalamic I h was increased in thalamocortical relay (TC) neurons, resulting in reduced cAMP responsiveness of I h."
reach
"We performed real-time quantitative RT-PCR and found that HCN1 mRNA expression in the CA1 hippocampus at 1 hr and 1 d post-SE was unchanged compared to control (1 hr, 124 +/- 9.1%, n = 6; 1 d, 90 +/- 14.4%, n = 6, p> 0.05 by ANOVA, XREF_FIG), showing that the loss of I h and HCN1 protein expression within the first day post-SE was not due to transcriptional downregulation of HCN1 mRNA expression."