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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCN5A activates luciferase reporter. 2 / 2

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"We first used a luciferase reporter driven by SCN5A 3 ' UTR to determine if let-7f suppresses SCN5A expression.We found that 48 h after transfection, let-7f miRNA mimics decreased normalized luciferase units by 55.9 +/-8.2% (0.169 +/-0.037 NLU) in HEK293 cells co-transfected with let-7f miRNA mimic and SCN5A 3 ' UTR, compared to cells transfected with the 3 ' UTR vector alone (0.406 +/-0.058 NLU; n = 6; p = 0.013, let-7f mimic to no-mimic controls by a two tailed paired t-test, XREF_FIG)."

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"We first used a luciferase reporter driven by SCN5A 3 ' UTR to determine if let-7f suppresses SCN5A expression."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...