IndraLab

Statements

STAMBP binds USP8 and STAM. 5 / 5
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sparser
"The functional relevance of the interaction between USP8, AMSH, and STAM in the endocytic trafficking of activated growth factors is supported by other observations, including that catalytically inactive AMSH, a potential “substrate trap” mutant, resulted in the accumulation of ubiquitin on endosomes, an increased association with STAM, and the generation of a minor product consistent with ubiquitylated STAM ( xref )."
16702236
sparser
"This also contains the sequence PPPRPTAPKP, which binds the Mona SH3 domain [ 39 ] and closely resembles the PXXXRXXKP motifs in UBPY [ 21, 28 ] and AMSH [ 20 ] that bind STAM SH3."
23477725
sparser
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non-canonical SH3-binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40] ."
22800866
sparser
"The molecular mechanism underlying these opposing effects is hinted at by the observation that USP8 and AMSH bind a central SH3 domain of STAM proteins in a mutually exclusive manner ( xref )."
16702236
sparser
"AMSH (a JAMM family member with specificity for K63 chains) and USP8 associate with STAM proteins, a component of the ESCRT-0 complex xref , xref ."
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