IndraLab

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USP17L2 activates Neoplasm Metastasis. 16 / 16
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"The authors correlated the stunting of tumor growth with the antagonizing role of palbociclib in DUB3-driven CDK4/6 activation, consequently preventing EMT and metastases [161]."
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"To directly assess whether Dub3 promotes metastasis in vivo, we intravenously injected Dub3-knockdown MDA-MB231 cells into female SCID mice and subjected these mice to bioluminescent imaging (BLI)."
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"Our results (shown in XREF_FIG and XREF_SUPPLEMENTARY) demonstrate DUB3 's ability to increase breast cancer cell migration and metastasis by targeting SNAIL1, thereby supporting our hypothesis that DUB3 promotes breast carcinoma metastasis in patients."
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"Dub3 is overexpressed in breast cancer; knockdown of Dub3 resulted in Snail1 destabilization, suppressed EMT and decreased tumour cell migration, invasion, and metastasis."
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"DUB3 (official symbol USP17L2) was shown to promote breast cancer invasion and metastasis via stabilizing Snail1 in a CDK4/6 activity-dependent manner ."
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"Dub3 knockdown after DOX treatment significantly decreased lung metastasis and lung weight, but these parameters showed no difference in control mice with or without DOX treatment (middle and right panels, XREF_FIG)."
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"Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation."
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"USP17 Knockdown Impairs Tumor Proliferation and Metastasis Through Targeting MMPs Because degradation of the basement membrane by MMPs is required for tumor cell migration and invasion ( 16,17 ) , we sought to determine whether MMPs were responsible for USP17-dependent growth and invasion ."
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"14 We previously demonstrated that CDK4/6 binds and phosphorylates DUB3 at Ser41, which is essential for the activation of DUB3 and stabilization of Snail1, thereby promoting EMT and metastasis in breast cancer."
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"Our previous study demonstrated that DUB3 was phosphorylated at Ser41 by CDK4/6, promoting cancer metastasis of triple‐negative breast cancer (TNBC)."
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"Recently, DUB3 has been demonstrated to promote breast cancer metastasis and hold the therapeutic potential for breast cancer [22, 44]."
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"For example, Dub3 inhibition suppresses invasion and metastasis of breast cancer by promoting Snail1 degradation [ 23 ]."
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"Inhibition of USP17 promotes SNAI1 degradation , thereby suppressing breast cancer invasion and metastasis ( 49 , 53 ) ."
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"For example, DUB3 can stabilize Snail1 via CDK4/6 and promote BC invasion and metastasis [50,51]."
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"These experimental findings suggested that Dub3 potentially promoted cancer growth and metastasis."
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"It has been reported that Snail1 pathway is involved in the progression of many diseases , for instance , Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation.25 CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer.26 Moreover , it has been reported that Snail1 has involved the progression of DN.27 Consistent with our research , mRNA and protein expression of Snail1 was decreased in PVT1-KD MCs , which was reversed by treating with miR-325-3p inhibitor ."
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