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Statements

EGF activates MAPK1. 14 / 14
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"PMA (100 nM) and EGF (25 ng/ml) induced the activation of ERK1/ ERK2 in glioblastoma cell lines "
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"activation of p42/p44 MAP kinase by endogenous epidermal growth factor, lysophosphatidic acid, and beta2-adrenergic receptors"
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"We show that Cdc2 inhibits EGF-mediated ERK activation through direct interaction and phosphorylation of several ERK pathway proteins, including the guanine nucleotide exchange factor, Sos-1, and Raf-1 kinase."
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" We previously reported that the epidermal growth factor (EGF) regulates the gene expression of keratin 16 by activating the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling which in turn enhances the recruitment of p300 to the keratin 16 promoter. "
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"Here, we show that exposure to 100 ng/ml EGF for 15 min, 1 U/ml GO for 30 min, or smoke from one cigarette for 45 min activates downstream ERK1/2 and Akt signaling (Fig. 7A) "
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"the activation of Erk and phospholipase C (PLC)-g observed following stimulation of HeLa cells with a low dose of EGF was accelerated and potentiated following co-treatment with a low dose of GA (Fig 2E)."
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"In this study we show that epidermal growth factor (EGF) strongly induces phosphorylation of ERK1/2 and Bad in HT29 colon cancer cells."
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"Figure 4 shows the inhibitory effect of gefitinib on EGFinduced autophosphorylation of EGFR, and phophorylation of Akt and ERK1/2 in three of the NSCLC cell lines. EGF stimulated EGFR autophosphorylation and activation of Akt and ERK1/2 in PC9 (A), A549 (B), and QG56 (C) cells, and activation was blocked to different extents by gefitinib."
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"EGF and thrombin triggered a rapid activation of the EGF receptor, followed by the phosphorylation and activation of the extracellular signal-regulated protein kinase (ERK)"
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"Dob and EGF each increased P-ERK1/2, effects that were significantly attenuated by EGFR inhibition (Fig. 1B). "
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"the ability of epidermal growth factor to inhibit PDE4D3 through ERK2 action inherent inhibitory effect that ERK2 phosphorylation exerts on the PDE4D catalytic unit"
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"Treating human Panc-48 adenocarcinoma cells with EGF activated Akt and Erk but not P-38."
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"epidermal growth factor induces immediate, ERK1/ERK2-dependent activation of endogenous ribosomal transcription inactivation of ERK1/ERK2 causes an equally immediate reversion to the basal transcription level"
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"expression of ATIP1 in eukaryotic cells leads to inhibition of insulin, basic fibroblast growth factor, and epidermal growth factor-induced ERK2 activation and DNA synthesis, and attenuates insulin receptor autophosphorylation"
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