IndraLab
Statements
USP14 increases the amount of gamma-aminobutyric acid. 2 / 2
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2
reach
"Colocalization experiments and in vitro binding studies further indicated that USP14 and GABA A receptors are found together at synapses, that the C-terminus of USP14 can interact with the alpha1 loop of the GABA A receptor, and that expression of a GABA receptor peptide that binds USP14 can promote expression of surface GABA A receptors in HEK cells [XREF_BIBR]."
reach
"Intriguingly, Usp14 binds the alpha1 GABA A receptor subunit, and ax J mice lacking Usp14 exhibit increased GABA A receptor levels at Purkinje cell-surface membranes and increased inhibitory postsynaptic currents (IPSCs), which suggest that ubiquitin dependent GABA A receptor turnover at cerebellar synapses contributes to behavioral impairment."