IndraLab

Statements


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"Significantly, it was established that USP11 is bonafide substrate of S6Kinase and phosphorylation of USp11 at Ser 453 regulates the recruitment of USP11 on cap complex as well as its interaction with eIF4B, thus increasing the eIF4B driven oncogenes expression."

No evidence text available

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"USP11 interacts and deubiquitinates eIF4B."

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"Fatty Acid Synthase induced S6Kinase facilitates USP11 and eIF4B complex formation for sustained oncogenic translation in DLBCL."

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"In light of this apparently conflicting observation based on in vitro and cell based deubiquitination assays, we next examined whether the interaction between USP11 and eIF4B was S6Kinase dependent."

No evidence text available

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"We showed before that fatty acid synthase is involved with DLBCL progression in part by inducing PI3K-Akt-S6Kinase signaling to enhance interactions a USP11-eIF4B complex ."

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"Finally, the interaction between eIF4B and USP11 is directly modulated by FASN mediated S6Kinase activity."