IndraLab

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MiR-130b decreases the amount of CYLD. 4 / 4
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"Thirdly, in J82 and Dox and T24 and Dox cells, western blot proved that miR-130b remarkably reduced the expression of CYLD protein (XREF_FIG)."
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"MiR-130b inhibited CYLD expression and activated NF-kappaB signaling."
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"In this study, we demonstrated that miR-130b suppressed CYLD expression at both the mRNA and protein levels."
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"Thus, the present study revealed that, in bladder cancer, NF-kappaB can maintain its activity by establishing a feedback loop, in which NF-kappaB induced the expression of miR-130b, which consequently inhibited the expression of CYLD, which in turn was an endogenous inhibitor of NF-kappaB activation."
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