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ERK phosphorylates STAT3. 62 / 62
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"Phosphorylation of STAT3 activates the ERK and Akt pathways, which also promote phosphorylation of STAT3."
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"Conversely, while the MEK1/2 inhibitor U0126 and the STAT3 inhibitor WP1066 both inhibited ERK and STAT3 phosphorylation, neither affected IDO expression."
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"It is now obvious that serine phosphorylation of STAT-3 by ERKs, p38, or Jun-N-terminal kinase [36] is required for maximal transcriptional activation of STAT-3 [37,38] , a situation which has also[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, trametinib, a mitogen activated protein and extracellular signal regulated kinase kinase (MEK) inhibitor, reduced the p-ERK level and significantly increased signal transducer and activator of transcription 3 (STAT3) phosphorylation in GC cells, resulting in reduced sensitivity to trametinib."
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"Phosphorylation of STAT3 and CREB can be directly or indirectly mediated by both MAPK p38 and ERK1/2 XREF_BIBR, XREF_BIBR."
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"Finally, ERK1/2 inhibition in naive mice decreased KIM-1 mRNA and nuclear STAT3 phosphorylation in the cortex, indicating homeostatic regulation of KIM-1."
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"It was reported that ERK phosphorylates and activates both STAT3 and Elk‐1 40, 41."
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"In FPR2-expressing RBL-2H3, cells the stimulation of FPR2 by WKYMVm induces ERKs phosphorylation and serine phosphorylation of STAT3 in a PTX-sensitive manner."
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"Both Akt and ERK are known to induce STAT3 phosphorylation independently of cytokine stimulation (Zhao et al., 2004)."
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"Specific inhibitors of p38 (SB203580), ERK (PD98059), and JNK (SP600125) inhibited MK1-EPS-induced HUVEC proliferation, tube formation, and cell migration, and partially attenuated MKI-EPS-induced expression of p21 and ICAM1, and STAT3 phosphorylation."
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"As shown in Fig. 3e1 and e2, IL-6 or IL-10 could enhance phosphorylation of STAT3 and AKT molecules but not ERK in B lymphocytes."
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"Mitochondrial STAT3 is phosphorylated by ERK1/2 and contributes to mast cell degranulation."
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"Our results also indicated that ERK1/2 and PI3K and AKT pathways result in phosphorylation of STAT3 and STAT5 in GBM."
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"Although previous studies clearly demonstrated serine phosphorylation of STAT3 regulates ERK, the current results indicate that ERK may also phosphorylate tyrosine on STAT3."
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"Since EGFR and ERK can directly phosphorylate and activate STAT3, we hypothesized that RPN2 might modulate the activity of STAT3 by EGFR glycosylation."
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"Two lines of evidence suggest that ERK kinases may phosphorylate STAT3 despite the fact that we could not visualize any interaction between STAT3 and ERK2 (not shown): ( a ) the sensitivity of the STAT3-containing complex to Herbimycin A, a potent inhibitor of tyrosine kinases that alters MAP kinase function in vivo; and ( b ) the finding that Ras, a known MAP kinase inducer, is involved in LIF signaling in ES cells ( xref , xref , xref )."
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"Inhibition of MEK and Erk pathway with PD98059 increased STAT3 phosphorylation and potentiated LPS induced activation."
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"Analysis of signal transduction pathways revealed that leptin stimulated phosphorylation of Akt and STAT3 but not ERK1/2."
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"We found that binding of neuronal uPA to astrocytic uPAR promotes astrocytic activation and that astrocytes activated by uPA-uPAR binding promote synaptic recovery in neurons that have suffered a hypoxic injury by a mechanism that does not require plasmin generation, but instead is mediated by ERK1/2 regulated STAT3 phosphorylation, astrocytic thrombospondin-1 (TSP1) and synaptic low-density lipoprotein receptor related protein-1 (LRP1)."
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"Furthermore, as a key transcription factor, STAT3 may be phosphorylated by ERK1/2 to drive biological functions in cancer cells [ xref ]."
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"OB3 peptide also induces STAT3 phosphorylation by ERK1/2 and PI3K-dependent signal transduction [ xref ]."
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"Interestingly, serine phosphorylation of STAT3 by ERK has been reported to negatively modulate STAT3 tyrosine phosphorylation and activity [ xref , xref ], while other studies implicate the MEK/ERK cascade in positively mediating STAT3 activity [ xref – xref ]."
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"Inhibition of either ERK1/2 (with U0126) or STAT-3 (with Ag490) abolished aloperine-induced anti-arrhythmic effects and ERK1/2 and STAT-3 phosphorylation."
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"Interestingly, STAT3 could be phosphorylated by Erks XREF_BIBR, while AIB1 and STAT3 are documented to be regulated by Pin1 XREF_BIBR, XREF_BIBR, indicating that a network of genes might play a role of " bumper " in sorafenib induced cell death."
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"Taken together, these results suggest that risperidone modulates SOCS3 and SOCS6 expression through adenylate cyclase mediated ERK activation, which, in turn, leads to an inhibition of insulin induced PKB phosphorylation and leptin stimulated STAT3 phosphorylation."
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"ERK1/2 does not induce STAT3 phosphorylation but, instead, represses STAT3 (tyr705 and ser727) phosphorylation and antagonizes STAT3 DNA binding capacities in the nucleus (XREF_FIG)."
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"ERK1/2 does not induce STAT3 phosphorylation but, instead, represses STAT3 (tyr705 and ser727) phosphorylation and antagonizes STAT3 DNA-binding capacities in the nucleus ( xref )."
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"We found that neurons release uPA and astrocytes recruit uPAR to their plasma membrane during the recovery phase from a hypoxic injury and that binding of neuronal uPA to astrocytic uPAR induces astrocytic activation by a mechanism that does not require plasmin generation, but instead is mediated by extracellular signal-regulated kinase 1/2 (ERK1/2)-regulated phosphorylation of the signal transducer and activator of transcription 3 (STAT3)."
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"Our results show that rapamycin induces ERK dependent phosphorylation of STAT3, which is causatively involved in reducing I/R injury in heart and cardiomyocytes."
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"Since the specific inhibitors of ERK signaling cascades, including Raf-1 and MEK, suppresses cicaprost induced STAT3 phosphorylations, the involvement of the classical Raf-1/MEK/ERK signaling cascade [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, it has been demonstrated that ERK1/2 can directly phosphorylate Ser727 at the C-terminus of STAT3 ( xref )."
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"These observations supported the hypothesis that STAT3 may be phosphorylated in mitochondria by activated ERK or other kinases."
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"Here, we show that STAT3 serine phosphorylation is induced by ERK and JNK as a downstream effect of FGFR signaling and it does not require over-expression of FGFRs."
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"These results reveal that Wnt5a affects IL-10 expression through the ERK1/2 and STAT3 pathways, and STAT3 is phosphorylated by ERK1/2."
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"Two lines of evidence suggest that ERK kinases may phosphorylate STAT3 despite the fact that we could not visualize any interaction between STAT3 and ERK2 (not shown) : (a) the sensitivity of the STAT3 containing complex to Herbimycin A, a potent inhibitor of tyrosine kinases that alters MAP kinase function in vivo; and (b) the finding that Ras, a known MAP kinase inducer, is involved in LIF signaling in ES cells."
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"ERK1/2 activation led to an increased phosphorylation of MSK1, p90RSK, and STAT3."
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"These changes are accompanied by activation of cytokine signalling mediated primarily through phosphorylation of STAT3 and p38 MAP kinase rather than ERK1/2."
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"Inactivation of ERK by PD98059 promoted phosphorylation of STAT3 (phospho Tyr 705), and neither Akt nor JNK affected the STAT3 activity in gastric cancer cells after DIF-1 stimulus XREF_BIBR."
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"Additionally, the knockdown suppressed phosphorylation of signal transducer and activator of transcription-3 in AA cells, and extracellular signal-regulated kinase (ERK) 1/2 in AA and OCI/AML2 cells; both are downstream molecules of TYRO3 signalling."
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"These observations supported the hypothesis that STAT3 may be phosphorylated in mitochondria by activated ERK or other kinases."
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"It has been reported that Y705-STAT3 phosphorylation can be negatively modulated by ERK induced phosphorylation of S727-STAT3 [ xref ]."
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"Primary cultures of human kidney, lung or skin fibroblasts were stimulated with IL11 that resulted in the transient phosphorylation of signal transducer and activator of transcription 3 (STAT3) and the sustained activation of extracellular signal-regulated protein kinases (ERK)."
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"STAT3 is one of the important downstream molecules in ERK pathway, activated ERK1/2 can enhance transcription activity by regulating the phosphorylation of STAT3 in nucleus XREF_BIBR, XREF_BIBR."
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"XREF_FIG, stimulation with thrombin also increased STAT3 phosphorylation and this enhanced STAT3 activation was antagonized by inhibitors of Src (PP2) and ERK (U0126) but not of FAK (PF573228)."
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"Interestingly, inhibition of ERK1/2 decreased SFKs phosphorylation, but markedly increased STAT3 phosphorylation (approximately 2.5-fold, P < 0.001)."
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"Phosphorylation at the serine 727 residue is critical for the translocation of STAT3 to the mitochondria, and interestingly, ERK may phosphorylate STAT3 at this residue [ xref ]."
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"” Multiple kinases from the MAPK pathway were shown to activate the JAK-STAT pathway including ERK (59) and JNK (60), which is known to phosphorylate STAT1 and STAT3 upon inhibition of the MAPK pathway (59)."
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"For example, ERK positively regulates serine (Ser727) phosphorylation of STAT3, which mediates transcriptional activity of STAT3 [ xref ]."
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"Blocking the ERK-induced serine phosphorylation of STAT3 with U0126, however, resulted in 50% reduction of transcriptional activity (1.9-fold induction vs 1.5-fold induction, respectively, <0.05)."
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"Furthermore, as a key transcription factor, STAT3 may be phosphorylated by ERK1/2 to drive biological functions in cancer cells [XREF_BIBR]."
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"Specifically, the phosphorylation of STAT3 was upregulated by 64 and 58%, of ERK1/2 by 65 and 49%, and of Akt by 21 and 55% in RF/6A and BCE, respectively."
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"Additionally, ERK1/2 phosphorylate members of the STAT transcription factor family (STAT1, STAT3, STAT4, and STAT5), which are known to mediate many aspects of survival, proliferation, differentiation [XREF_BIBR], cytokine dependent inflammation [XREF_BIBR], and apoptosis [XREF_BIBR]."
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"ERK1/2 promotes STAT3 phosphorylation [ xref ], and crosstalk between STAT3 and MEK-Erk1/2 pathways in other tissues have been reported [ xref – xref ]."
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"It was reported that ERK phosphorylates and activates both STAT3 and Elk-1 40, 41."
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"These results suggest that JAK2 and ERK may mediate tyrosine and serine phosphorylation of STAT3 induced by histamine, respectively, and that both phosphorylations may be required for the activation o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Tyr phosphorylation of Erk and Ser phosphorylation of STAT-3 were inhibited by PD98059, while Tyr phosphorylation of STAT-3 was not inhibited by PD98059."
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"Together with p38 MAP kinase, ERK can also phosphorylate S727 STAT3[ xref ]."
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"Moreover, ERK1/2 inhibition suppressed STAT3 phosphorylation, and STAT3 inhibition disrupted the nuclear translocation of pERK1/2 induced by tensile loading."
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"PERK1/2 phosphorylates c-Jun ( xref ) and STAT3 ( xref ), which are two transcriptional factors that stimulate the expression of specific RAGs such as vip , npy , and sprr1a ( xref xref xref )."
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"Previous reports also demonstrated that ERK family of mitogen-activated protein kinases, but not JNK or p38, phosphorylates and activates STAT3 in response to growth factors. xref We therefore detected the phosphorylation of STAT3 at tyrosine 705 (Y705) and serine 727 (S727) in melanocytes after the stimulation of FGF2 in human primary melanocytes."
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"Moreover, knockdown of ERK1/2 and upstream regulator MEK1/2 (mitogen activated protein kinase kinase1/2) by siRNAs also limited STAT3 phosphorylation and increased resistance to erastin in PANC1 cells[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Other cellular intrinsic signals, such as p-Erk1/2, phosphorylated signal transducer and activator of transcription 3 (p-STAT3), and p-Akt, have also been linked to the self-renewal, proliferation, and differentiation in different kinds of stem cells [XREF_BIBR - XREF_BIBR]."
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