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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to NQO1 activates TP53. 2 / 2

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"In contrast, dicumarol, and other inhibitors that compete with NAD (P) H, disrupted the binding of NQO1 and p53 and caused ubiquitin independent p53 degradation [XREF_BIBR, XREF_BIBR], whereas binding of NQO1 to p53 (and p73alpha, see below) was enhanced by addition of NADH, but not by NAD or FAD [XREF_BIBR]."

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"NQO1 has protective effect against the development of Alzheimer 's disease as well as binds to p53 and inhibits p53 degradation in an ubiquitin independent pathway via the 20S proteasome."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...