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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Phosphorylated TSC2 inhibits MTOR. 2 / 2

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"Moreover, the phosphorylated TSC2 can participate in stimulating cell growth and suppress mTOR signaling (69)."

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"In this regard, LKB1 mediated AMPK activation leads to accumulation of phosphorylated TSC2 [XREF_BIBR], which inhibits mTOR signaling by blocking phosphorylation of its two key translational regulators, p70 ribosomal S6 kinase 1 (S6K) and eukaryote initiation factor 4E binding protein 1 (4E-BP1) (XREF_FIG) [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...