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(-)-epigallocatechin 3-gallate inhibits ITCH. 12 / 12
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"(D-E) Systemic administration of PBN (10-300 mg/kg; i.p.) and EGCG (50-200 mg/kg; i.p.) dose-dependently attenuated CQ induced itch in mice (C, F) Local administration of EGCG (50-200 mug; i.p.) dose-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, EGCG treatment remarkably inhibited p-ERK and p-AKT in the spinal cord of mice in compound 48/80 induced acute itch and PSO induced chronic itch, respectively."
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"Instead, EGCG inhibited p-AKT activation in the spinal cord dorsal horn by imiquimod induced psoriatic itch in mice."
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"In the present study, we found EGCG reduced both histamine dependent and -independent itch, possible through multiple mechanisms in the periphery and central nervous system.Oxidative stress has long b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EGCG also attenuated imiquimod induced chronic psoriatic itch behaviors and skin epidermal hyperplasia in mice."
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"Thus, these results indicated that green tea polyphenon 60 or EGCG inhibited acute histamine dependent itch in mice.EGCG attenuated chloroquine (CQ)-induced histamine independent acute itch in mice.We[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Application of EGCG also attenuated imiquimod induced chronic psoriatic itch."
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"Taken together, these results indicated EGCG inhibited acute and chronic itch through distinct pathways in the spinal cord.In summary, we have demonstrated that green tea polyphenon 60 or EGCG treatme[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, EGCG attenuated both histamine dependent and -independent acute itch, possible through decreasing the accumulation of ROS in primary sensory neurons."
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"Thus, the results showed that green tea polyphenon 60 or EGCG also inhibited acute histamine independent itch in mice.Our previous study found that oxidative stress contributed to compound 48/80 and C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the present study, we demonstrated that systemic administration of polyphenon 60 or EGCG, dose-dependently attenuated compound 48/80- and CQ induced acute itch in mice."
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"In the present study, we asked whether EGCG reduced itch by suppression of oxidative stress."
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