IndraLab

Statements

USP14 inhibits BECN1. 5 / 6
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"Recently, USP14 was found to directly interact with and inhibit the critical autophagy protein BECN1 in a proteasomal independent manner 66."
29995557
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"Here, USP14 negatively regulated autophagy in a Beclin-1- and Akt-dependent manner."
36831318
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"Nevertheless, the precise molecular mechanism by which USP14 suppresses Beclin 1 remains unclear."
29326710
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"Although the role of USP14 can not be completely ruled out as a proteasome associated DUB enzyme that can affect the expression of TRAF6, these results suggest that USP14 inhibits the interaction of Beclin 1 to TRAF6 through the competitive interaction to TRAF6 with Beclin 1."
29326710
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"According to this observation, it was shown that USP14 suppresses the activity of Beclin1 complex and induction of autophagy by interacting with and controlling K63- rather than K48 linked ubiquitin chains of Beclin1 [XREF_BIBR]."
30126257