IndraLab

Statements

USP14 inhibits BECN1. 3 / 4
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reach
"According to this observation, it was shown that USP14 suppresses the activity of Beclin1 complex and induction of autophagy by interacting with and controlling K63- rather than K48 linked ubiquitin chains of Beclin1 [XREF_BIBR]."
30126257
reach
"Although the role of USP14 can not be completely ruled out as a proteasome associated DUB enzyme that can affect the expression of TRAF6, these results suggest that USP14 inhibits the interaction of Beclin 1 to TRAF6 through the competitive interaction to TRAF6 with Beclin 1."
29326710
reach
"Nevertheless, the precise molecular mechanism by which USP14 suppresses Beclin 1 remains unclear."
29326710