IndraLab

Statements

USP10 activates PTEN. 5 / 5
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"Specifically, USP10 activates PTEN by preventing its K63-linked polyubiquitination mediated by TRIM25 and suppresses the AKT/mTOR signaling pathway thereby inhibiting NSCLC proliferation, indicating that it may be a potential drug target for cancer treatment."
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"Specifically, USP10 activates PTEN by preventing its K63 linked polyubiquitination mediated by TRIM25 and suppresses the AKT and mTOR signaling pathway thereby inhibiting NSCLC proliferation, indicating that it may be a potential drug target for cancer treatment."
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"Specifically , USP10 activates PTEN by preventing its K63-linked polyubiquitination mediated by TRIM25 and suppresses the AKT / mTOR signaling pathway thereby inhibiting NSCLC proliferation , indicating that it may be a potential drug target for cancer treatment ."
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"The deubiquitinase USP10 restores PTEN activity and inhibits non small cell lung cancer cell proliferation."
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"In contrast to TRIM25, USP10 restored PTEN phosphatase activity and reduced the production of the secondary messenger PI (3,4,5) P3, thereby inhibiting AKT and mTOR pro growth signaling transduction in NSCLC cells."
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