IndraLab

Statements

USP10 activates PTEN. 12 / 12
| 1 7 4
sparser
"xref demonstrated that USP10 activates phosphatase and tensin homolog (PTEN) by removing the K63-linked polyubiquitin chain from PTEN, thereby inhibiting the AKT/mTOR signalling pathway and ultimately suppressing the proliferation of NSCLC tumour cells."
41635813
reach
"By countering TRIM25, USP10 rescues PTEN phosphatase activity and reduces the production of PI(3,4,5)P3 in NSCLC cells, therefore inactivating the AKT/mTOR signaling pathway in NSCLC cells (Fig. 5)."
34416231
reach
"The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation."
34416231
reach
"In contrast to TRIM25, USP10 restored PTEN phosphatase activity and reduced the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate, thereby inhibiting AKT/mammalian target of rapamycin progrowth signaling transduction in NSCLC cells."
34416231
reach
"Our aforementioned studies have shown that USP10 restores the phosphatase activity of PTEN, thereby inhibiting the AKT/mTOR signaling."
34416231
sparser
"These data thus demonstrated that USP10 might activate PTEN, thus inhibiting the AKT/mTOR signaling pathway."
34416231
reach
"Given that TRIM25-mediated K63-linked ubiquitination does not alter PTEN stability (10), and USP10 prevents PTEN from K63-linked polyubiquitination mediated by TRIM25, we wondered whether PTEN stability was modulated by USP10."
34416231
sparser
"Specifically, USP10 activates PTEN by preventing its K63-linked polyubiquitination mediated by TRIM25 and suppresses the AKT/mammalian target of rapamycin signaling pathway, thereby inhibiting NSCLC proliferation, indicating that it may be a potential drug target for cancer treatment."
34416231
reach
"These data thus demonstrated that USP10 might activate PTEN, thus inhibiting the AKT/mTOR signaling pathway."
34416231
reach
"Moreover, although it is downregulated in NSCLC cells, restoration of USP10 can activate PTEN, therefore decreasing the production of PI(3,4,5)P3 and suppressing the AKT/mTOR signaling transduction and inhibiting NSCLC cell proliferation and migration."
34416231
sparser
"Finally, USP10 influences the AKT signaling pathway and activates phosphatase and tensin homolog (PTEN) by blocking its K63-linked polyubiquitination, which in turn suppresses the growth of NSCLC [ xref , xref ]."
35884607
eidos
"Specifically , USP10 activates PTEN by preventing its K63-linked polyubiquitination mediated by TRIM25 and suppresses the AKT / mTOR signaling pathway thereby inhibiting NSCLC proliferation , indicating that it may be a potential drug target for cancer treatment ."
34416231