IndraLab

Statements

USP18 inhibits STAT. 16 / 19
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"USP18 negatively regulates JAK–STAT signalling independently of its isopeptidase activity by binding to the IFNAR2 sub-unit of the type 1 interferon receptor and interfering with the JAK receptor interaction [18,19]."
37756534
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"It has been reported that C-terminal region of USP18 (amino acid residue 312-368) competes with Jak1 for interacting with the type I IFN receptor (IFNAR2) and represses downstream Jak and STAT signaling pathway [XREF_BIBR]."
29285303
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"Suppression of USP18 activated the JAK and STAT signaling pathway as shown by the increased and prolonged expression of phosphorylated signal transducer and activator of transcription 1 (p-STAT1) in combination with enhanced expression of several interferon stimulated genes (ISGs)."
27227879
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"Usp18 can inhibit JAK/STAT signaling, while Calb2 is an unreported regeneration response, suggesting that JAK-STAT signaling may mediate the expression of immune-related genes in SCs of the chicken basilar papilla following HC damage, thus leading to the regeneration of new HCs."
38015350
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"22 , 23 With the establishment of BV2 microglial cells under oxygen and glucose deprivation (OGD) and middle cerebral artery occlusion (MCAO) in mice as models of ischemia, the results from Xiang and his partners suggested that the ubiquitin‐specific protease 18 (USP18) reduced HI injury via the suppression of microglial activation by negatively inhibiting the JAK‐STAT pathway."
37786415
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"Taken together, we concluded that USP18 potentiates the anti-HBV activity of IFN-alpha by targeting the JAK and STAT signaling pathway in Hepg2.2.15 cells."
27227879
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"As expected, exogenous USP18 expression significantly inhibited IFN-a-induced Jak and STAT signaling as shown by decreased p-STAT1 levels and ISRE activity."
29285303
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"Moreover, USP18 competitively inhibits IFN-alpha and beta-induced JAK and STAT activation [XREF_BIBR] and upregulates epidermal growth factor receptor (EGFR) expression [XREF_BIBR]."
26046984
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"Under physiological conditions, USP18 inhibits STAT signaling, decreasing IFNalpha induced chemokine production and activation of several members of the BH3-only protein family."
23152055
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"Our findings indicate that USP18 inhibition induces inflammation by increasing the STAT signaling and exacerbates IFN induced beta cell apoptosis by the mitochondrial pathway of cell death."
23152055
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"In both IFN α/β-treated and untreated USP18-knockdown cells, USP18 negatively regulates the JAK/STAT pathway to amplify and strengthen IFN signalling [ 43 ]."
36934584
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"Through IFNAR1/2 receptors and the JAK/STAT signaling pathway, IFN-I has a further impact on the next important component of the development of the inflammatory response: the ISG15/USP18 axis, which regulates the activity of the immune system [36] and reduces the inflammatory response intensity by inhibiting the JAK/STAT signaling pathway, indicating that there possibly exists a negative feedback loop between USP18, IFN-I, and, therefore, TNF-α [43, 44]."
39188267
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"USP18 competes with JAK1 for IFNAR2 receptor binding, reducing JAK1 and STAT activation (15, 16)."
38938568
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"We next examined the effect of USP18 inhibition on the kinetics of IFNalpha induced STAT signaling activation."
23152055
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"In humans, USP18 negatively regulates the JAK–STAT signaling pathway, and is therefore considered to be an inhibitor of type-I anti-viral signaling ( Malakhov et al., 2002, 2003 )."
25446846
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"Other negative regulators include the PIAS (protein inhibitors of activated STAT) and PTP (protein tyrosine phosphatases) family proteins as well as ISG15 and USP18, which is a ubiquitin specific peptidase-18 – a deubiquitinating protease for removing ISG15 conjugate in a process known as delSGylation."
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