IndraLab

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USP18 inhibits STAT. 10 / 13
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"Moreover, USP18 competitively inhibits IFN-alpha and beta-induced JAK and STAT activation [XREF_BIBR] and upregulates epidermal growth factor receptor (EGFR) expression [XREF_BIBR]."
26046984
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"Suppression of USP18 activated the JAK and STAT signaling pathway as shown by the increased and prolonged expression of phosphorylated signal transducer and activator of transcription 1 (p-STAT1) in combination with enhanced expression of several interferon stimulated genes (ISGs)."
27227879
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"As expected, exogenous USP18 expression significantly inhibited IFN-a-induced Jak and STAT signaling as shown by decreased p-STAT1 levels and ISRE activity."
29285303
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"Protein lysates were collected on day 4 postinfection and Gagp24 and USP18 expression were assessed by Western blotFigure 4: siRNA knockdown of USP18 enhances STAT activation and expression of ISGs in IFN‐β‐treated MDMs."
29437254
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"It has been reported that C-terminal region of USP18 (amino acid residue 312-368) competes with Jak1 for interacting with the type I IFN receptor (IFNAR2) and represses downstream Jak and STAT signaling pathway [XREF_BIBR]."
29285303
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"After 24 h, genomic DNA was collected and a qPCR assay developed to measure integrated proviral genomes showed that there were on average 3800 genomes per 10,000 cells in USP18 +/+ iMacs and on average 4900F I G U R E 4 siRNA knockdown of USP18 enhances STAT activation and expression of ISGs in IFN--treated MDMs.MDMs from 6 donors were transfected with nontargeting (NT) control or USP18 siRNA for 3 h followed by IFN-treatment for 18 h. (A) Expression of p-STAT1, p-STAT2, and USP18 was measured by Western blot."
29437254
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"Under physiological conditions, USP18 inhibits STAT signaling, decreasing IFNalpha induced chemokine production and activation of several members of the BH3-only protein family."
23152055
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"We next examined the effect of USP18 inhibition on the kinetics of IFNalpha induced STAT signaling activation."
23152055
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"Our findings indicate that USP18 inhibition induces inflammation by increasing the STAT signaling and exacerbates IFN induced beta cell apoptosis by the mitochondrial pathway of cell death."
23152055
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"Taken together, we concluded that USP18 potentiates the anti-HBV activity of IFN-alpha by targeting the JAK and STAT signaling pathway in Hepg2.2.15 cells."
27227879