IndraLab

Statements

Azithromycin inhibits STAT1. 3 / 3
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"Azithromycin polarizes macrophages towards an anti-inflammatory M2 phenotype, and inhibits pro-inflammatory STAT1 and NFκB signaling pathways [139, 140] ."
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"Moreover, we suggest that azithromycin might also disrupt the NF-κB and signal transducer and activator of transcription-1 synergistic induction of inflammatory genes expression that could also play a role in the dysregulated COVID-19 immune response (Hiroi and Ohmori 2005; Xing and Liu 2021)."
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"The exact mechanism of macrolide-based macrophage polarization is poorly understood, but azithromycin has been shown to inhibit NFκB and STAT1 signaling pathways in vitro."
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