IndraLab

Statements

Azithromycin inhibits STAT1. 4 / 4
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"Azithromycin inhibited STAT1/NFkβ signaling and polarized macrophages from the M1 to the M2-like phenotype [119] ."
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"Moreover, we suggest that azithromycin might also disrupt the NF-κB and signal transducer and activator of transcription-1 synergistic induction of inflammatory genes expression that could also play a role in the dysregulated COVID-19 immune response (Hiroi and Ohmori 2005; Xing and Liu 2021)."
34822026
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"The exact mechanism of macrolide-based macrophage polarization is poorly understood, but azithromycin has been shown to inhibit NFκB and STAT1 signaling pathways in vitro."
35367307
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"Preclinical studies have indicated that azithromycin may inhibit various pro-inflammatory signaling pathways, including NFκB, STAT1, and inflammasome activation, resulting in reduced production of pro-inflammatory cytokines such as TNF and IL-1β and shifted macrophage polarization (311–313)."
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