IndraLab

Statements

PAN2 binds PABP. 4 / 4
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reach
"The modest amount of endogenous PABP in the precipitate (XREF_FIG) suggests an indirect association between HA-Pan2 and PABP, presumably mediated via Pan3-V5, as HA-Pan2 alone did not pull down PABP (XREF_FIG)."
18625844
reach
"We have previously reported that mRNA decay is triggered by translation termination and proposed a model for the initiation of mRNA decay: after translation termination, the termination factors eRF1–eRF3 dissociate from PABP bound to the 3′ poly(A) tail, and in turn, Pan2–Pan3 and Caf1–Ccr4 deadenylases associate with PABP, which leads to the activation of the deadenylases and shortening of the poly(A) tail (6,7)."
30395302
sparser
"To study the contribution of each Pan3 domain to the interactions of Pan3 isoforms with PABP and Pan2, we created a series of domain truncation mutants of both Pan3 isoforms ( xref A) for co-IP experiments using both NIH3T3 and BEAS-2B cells."
28559491
sparser
"As Pan3 is a PABP-interacting protein ( xref ; xref ; xref ) that regulates Pan2 activity ( xref ; xref ; xref ; xref ; xref ; xref ; xref ; xref ), we conducted co-IP experiments to analyze the two Pan3 isoforms’ ability to interact with PABP or Pan2."
28559491