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Calcium(2+) activates KCNQ2. 3 / 3
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"Thus, Ca 2 + / CaM can partially restore the assembly and traffic of KCNQ2 and KCNQ3-I 342A channels in neurons, but a high proportion of these proteins is still held in the intracellular compartment."
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"Nonetheless, we find that Ca 2 + / CaM promotes the heteromeric assembly of KCNQ2 and KCNQ3-I 342A channels through binding to the B helices of KCNQ2 and KCNQ3-I342A subunits."
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"Structural rearrangements resolved by NMR of the CaMBD in KCNQ2 channels produced by Ca show that the N-lobe/helix B complex remains almost unchanged, whereas the initial part of helix A bents by about 18° concomitant to a torsion of the C-lobe around the helix A axis [121]."
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