IndraLab

Statements

Ubiquitin inhibits USP2. 11 / 11
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"In summary, our data show that the ubiquitin core and the ubiquitin C terminus alone bind USP2 very weakly with affinities at best in the high micromolar range, while full-length ubiquitin inhibits USP2 with a K i of 2.8 μM."
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"Ubv2.3 is an engineered Ub variant, known to selectively inhibit USP2, which has C-terminal in close proximity to the catalytic active site."
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"While ubiquitin inhibits USP2 with a K of 2.8 μM, mutants lacking residues Arg74-Gly75-Gly76 or Leu73-Arg74-Gly75-Gly76 affect the proteolytic activity of USP2 only marginally even at the highest inhibitor concentration."
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"While ubiquitin inhibits USP2 with a K i of 2.8 μM, mutants lacking residues Arg74-Gly75-Gly76 or Leu73-Arg74-Gly75-Gly76 affect the proteolytic activity of USP2 only marginally even at the highest inhibitor concentration."
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"Figure 4 : USP2 Inhibition by Full-Length Ubiquitin and the C-Terminally Truncated Mutants , Ubiquitin 1-74 and 1-73 Residual enzymatic activity was determined at 22degreesC with ubiquitin-AMC as substrate ."
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"We therefore equipped a synthetic Ub variant, which is known to inhibit USP2 (Ubv2.3), with an aldehyde warhead at the C-terminus to improve its potency (Figure 4A)."
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"Inhibition of USP2 by Ubiquitin and Ubiquitin Truncation Mutants."
16905103
eidos
"While ubiquitin inhibits USP2 with a Ki of 2.8 muM , mutants lacking residues Arg74-Gly75-Gly76 or Leu73-Arg74-Gly75-Gly76 affect the proteolytic activity of USP2 only marginally even at the highest inhibitor concentration ."
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"Inhibition of USP2 by Ubiquitin and Ubiquitin Truncation Mutants."
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"USP2 is inhibited by ubiquitin with a K i of 2.8 μM, which is in the same range as the K i of 3 μM for the related enzyme USP5, also known as isopeptidase T ( xref )."
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"USP2 is inhibited by ubiquitin with a K of 2.8 μM, which is in the same range as the K of 3 μM for the related enzyme USP5, also known as isopeptidase T (Dang et al., 1998)."
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