IndraLab

Statements

MTOR phosphorylates EIF4EBP1 on T36. 8 / 16
3 | 3 5 4
reach
"MTOR readily phosphorylated T36 PHAS-I and T45 PHAS-I under conditions in which S64 PHAS-I, T69 PHAS-I, and S82 PHAS-I were not significantly phosphorylated."
10405182
reach
"RAFT1 phosphorylation of 4E-BP1 on Thr 36 and Thr 45 blocks its association with the cap binding protein, eIF-4E, in vitro, and phosphorylation of Thr 45 seems to be the major regulator of the 4E-BP1-eIF-4E interaction in vivo."
9465032
reach
"Current evidence suggests that mTOR phosphorylates 4E-BP1 on two residues, Thr36 and Thr45 [33] ."
15659336
sparser
"RAFT1 phosphorylation of 4E-BP1 on Thr-36 and Thr-45 blocks its association with the cap-binding protein, eIF-4E, in vitro, and phosphorylation of Thr-45 seems to be the major regulator of the 4E-BP1-eIF-4E interaction in vivo."
9465032
sparser
"Recent findings suggests that Thr36 and Thr45 in PHAS-I are preferentially phosphorylated by mTOR [14] ."
10405182
sparser
"mTAb1-activated mTOR phosphorylated Thr36, Thr45, Ser64, Thr69, and Ser82 in PHAS-I. All five of these sites fit a (Ser/Thr)-Pro motif and are dephosphorylated in response to rapamycin in rat adipocytes."
9405468
sparser
"The present study has confirmed that mTOR (or a tightly associated kinase) phosphorylates 4E-BP1 at T 36 and/or T 45 and has identified an mTOR-associated kinase which phosphorylates 4E-BP1 within a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10471835
sparser
"Current evidence suggests that mTOR phosphorylates 4E-BP1 on two residues, Thr36 and Thr45 [33] ."
15659336