IndraLab

Statements

AKT phosphorylates USP14 on S432. 18 / 19
| 4 8 6
rlimsp
"To further verify the phosphorylation of USP14 S432 by Akt, we developed a phospho-Ser432-specific antibody."
26523394
sparser
"To further verify the phosphorylation of USP14 S432 by Akt, we developed a phospho-Ser432-specific antibody."
26523394
sparser
"Akt phosphorylates USP14 at the Ser432 residue, resulting in activation of its deubiquitylating activity [ xref ]."
28659380
sparser
"At the post-translational level, USP14 is phosphorylated on Ser432 by the growth-regulatory kinase AKT, which results in partial activation of its deubiquitinating activity ( xref )."
30833452
sparser
"As the proteasomal activity of USP14 is regulated by Akt-dependent phosphorylation of USP14 on S432 ( xref ), we investigated whether AKT impacts on the nuclear function of USP14."
31740976
reach
"Akt phosphorylates USP14 at the Ser432 residue, resulting in activation of its deubiquitylating activity [XREF_BIBR]."
28659380
sparser
"Phosphorylation of USP14 on Ser432 by Akt."
26523394
reach
"Phosphorylation of USP14 on Ser432 by Akt."
26523394
rlimsp
"From these results, we conclude that Ser432 of USP14 is a major phosphorylation site by Akt."
26523394
rlimsp
"Phosphorylation of USP14 on Ser432 by Akt."
26523394
rlimsp
"(A) In vitro phosphorylation of USP14 at S432 by Akt."
26523394
sparser
"Xu et al. report that the protein kinase AKT phosphorylates the deubiquitinase USP14 at Ser432 and Ser143 in vitro and in overexpression experiments, and that the phosphorylation of Ser432 is accompanied by a large increase in USP14 catalytic activity."
26523394
reach
"At the post-translational level, USP14 is phosphorylated on Ser432 by the growth-regulatory kinase AKT, which results in partial activation of its deubiquitinating activity."
30833452
sparser
"A recent study showed that the phosphorylation by AKT on the highly conserved Ser432 of USP14 enhances the DUB activity in proteasome in vitro and cells, and this is critical in regulating proteasome activity and, consequently, global protein degradation [ xref ]."
32512887
reach
"To further verify the phosphorylation of USP14 S432 by Akt, we developed a phospho-Ser432-specific antibody."
26523394
rlimsp
"Ubiquitin-specific protease-14 (USP14) is phosphorylated at Ser432 by activated Akt."
26523394
rlimsp
"We report that Akt-mediated phosphorylation of USP14 at Ser432, which normally blocks its catalytic site in the inactive conformation, activates its deubiquitinating activity in vitro and in cells."
26523394
sparser
"The growth factor signaling transducer Akt phosphorylates USP14 on Ser 432 resulting in an active conformation, thus providing means of globally regulating protein turnover ( xref )."
33324551