IndraLab

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RBX1 bound to SKP1 and CUL1 decreases the amount of EIF3F. 1 / 1

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"Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome."

18354498

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IndraLab

Statements

RBX1 bound to SKP1 and CUL1 decreases the amount of EIF3F. 1 / 1

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