IndraLab

"Analysis of the genomic constellations shows five genotypes (KH1-KH5) of clade 2.3.2.1c viruses circulated in Cambodia from 2014 to 2016 ( xref )."

"Our model for PRRSV −2/−1 PRF is that PCBPs interact with the PRRSV mRNA through KH1 and KH3, with each domain contacting one of the two C-patches (CCCA and CUCC) within the C-rich region."

"Nine haplotypes belonged to the K1 family (KH1–KH9), nine belonged to the MAD20 family (MH1–MH8, haplotype MH3 was translated from two nucleotide sequences, MH3-1 and MH3-2), and four belonged to the RO33 family (RH1–RH4)."

"H5N1 HPAI viruses belonging to clade 2.3.2.1c have been dominant since the beginning of 2014, with various genotypes (KH1-KH5) reported."

"We found that the KH2 can interact with both KH1 and KH3, and KH3 alone can activate the reporter gene expression in yeast cells ( xref )."

"It is well known that post‐transcriptional modifications of messenger RNAs (mRNAs), among which m 6 A is the most abundant internal RNA modification, regulate genes expression by influencing mRNA splicing, stability, translocation and translation. [ xref ] m 6 A modification is deposited by “writers” the methyltransferase complex containing the methyltransferase‐like 3 and 14 proteins (METTL3 and METTL14) and their regulator Wilms tumor 1‐associated protein, and removed by “erasers” demethylases: fat mass and obesity‐associated protein (FTO) and α‐ketoglutarate dependent dioxygenase AlkB homolog 5 (ALKBH5). [ xref , xref , xref , xref ] Moreover, m 6 A modification exerts its biological functions by “readers”: YTH (YT521‐B homology) domain proteins including YTHDC1–2 and the YTH‐family proteins YTHDF1–3 as well as insulin‐like growth factor 2 mRNA binding proteins IGF2BP1–3. [ xref ] Among these m 6 A readers, IGF2BP2 binds RNA via its six characteristic RNA‐binding domains, containing two RNA recognition motifs (RRM1 and RRM2) and four K Homology (KH) domains (KH1–KH4). [ xref ] Dysregulation of IGF2BP2 is implicated in certain diseases such as diabetes and cancer, nevertheless, little is known about IGF2BP2's functions in immunity."