IndraLab

"Analysis of the genomic constellations shows five genotypes (KH1-KH5) of clade 2.3.2.1c viruses circulated in Cambodia from 2014 to 2016 ( xref )."

"The approximate oral activities for peptides that elicited a significant response after oral administration were calculated by comparing the areas under the curve for induced hypothermia after IP and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"In addition, the N-terminal amine was replaced with an azido (KH1–KH27) or methyl (KH28–KH30) functionality to block aminopeptidase degradation and increase lipophilicity."

"The maximal hypothermic effects of NT(8–13), KH1–KH30, and KK13 after an IP or oral dose are given in Table 2 ."

"It possesses several RNA-binding structural domains, namely four C-terminal heterologous ribonucleoprotein K homology (KH) (KH1-KH4) domains and two N-terminal RNA recognition motifs [ xref ], and are involved in the regulation of a wide range of RNA processing mechanisms, such as localization, stability, and translation [ xref ]."

"A comparison of the hypothermic effects elicited by the N-terminal azido analogues (KH1–KH27) after IP dosing demonstrated that KH11, KH24, and KH26 elicit a response significantly greater than all ot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Specifically, pcbp interacts with PRRSV mRNA through KH1 and KH3, with each domain linked to one of two C-patches (CCCA and CUCC) in the C-rich region, which is located in the sliding sequence (GG GUU UUU) approximately 10 bp downstream."

"We found that the KH2 can interact with both KH1 and KH3, and KH3 alone can activate the reporter gene expression in yeast cells ( xref )."

"It contains three K-homology domains (KH1-KH3) responsible for nucleic acid binding, one K protein interactive domain (KI) responsible for protein binding, and a nuclear-cytoplasmic shuttling domain (KNS) that confers the ability to translocate bidirectionally through the nuclear pore complex."

"IGF2BP2, as an m 6 A “reader”, binds RNA through six RNA-binding domains, two of which contain RNA recognition motifs (RRM1 and RRM2) and four KH domains (KH1-KH4) [ xref ]."

"It is well known that post‐transcriptional modifications of messenger RNAs (mRNAs), among which m 6 A is the most abundant internal RNA modification, regulate genes expression by influencing mRNA splicing, stability, translocation and translation. [ xref ] m 6 A modification is deposited by “writers” the methyltransferase complex containing the methyltransferase‐like 3 and 14 proteins (METTL3 and METTL14) and their regulator Wilms tumor 1‐associated protein, and removed by “erasers” demethylases: fat mass and obesity‐associated protein (FTO) and α‐ketoglutarate dependent dioxygenase AlkB homolog 5 (ALKBH5). [ xref , xref , xref , xref ] Moreover, m 6 A modification exerts its biological functions by “readers”: YTH (YT521‐B homology) domain proteins including YTHDC1–2 and the YTH‐family proteins YTHDF1–3 as well as insulin‐like growth factor 2 mRNA binding proteins IGF2BP1–3. [ xref ] Among these m 6 A readers, IGF2BP2 binds RNA via its six characteristic RNA‐binding domains, containing two RNA recognition motifs (RRM1 and RRM2) and four K Homology (KH) domains (KH1–KH4). [ xref ] Dysregulation of IGF2BP2 is implicated in certain diseases such as diabetes and cancer, nevertheless, little is known about IGF2BP2's functions in immunity."

"H5N1 HPAI viruses belonging to clade 2.3.2.1c have been dominant since the beginning of 2014, with various genotypes (KH1-KH5) reported."

"Nine haplotypes belonged to the K1 family (KH1–KH9), nine belonged to the MAD20 family (MH1–MH8, haplotype MH3 was translated from two nucleotide sequences, MH3-1 and MH3-2), and four belonged to the RO33 family (RH1–RH4)."