IndraLab

Statements

CYLD inhibits growth. 3 / 3
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"Compared to transfection with an empty vector control, wild-type CYLD transfection reduced hypoxia-induced colony formation, whereas as the C/S-CYLD mutant did not ( xref ), findings which indicates that CYLD inhibits hypoxia-induced anchorage-independent growth."
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"Consistently, CYLD but not its catalytically deficient mutant inhibited subcutaneous melanoma growth in immunodeficient mice, which is accompanied by the downregulation of cyclin D1 and N-cadherin and the upregulation of E-cadherin and p53."
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"In order to explore how CYLD inhibits invasive tumor growth, we examined the expression status of β1-integrin which is a member of the heterodimeric transmembrane receptors involved in melanoma migration and chemotaxis ( xref ; xref )."
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