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USP10 activates USP10. 7 / 8
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"However, although DAAM1-actin binding is not required for its inhibitory activity on USP10, our experiments demonstrate that DAAM1 may sequester USP10 to actin-stress fibers: Treatment with TGFβ1 enhanced the proximity between USP10 and DAAM1 and promoted co-localization with actin-stress fibers (Fig. 4 and Supplemental Fig 4) and DAAM1 knockdown caused a concomitant loss of USP10 from stress fibers (Fig. 5)."
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"In order to elevate the role of USP10 in sensitivity to DOX of thyroid cancer cells and based on the experimental results of its abnormally low expression, pcDNA-USP10 was transfected into FTC133 and FTC133-DOX cells to overexpress expression of USP10."
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"For example, as AMPK-mediated phosphorylation of USP10 enhances USP10 activity , treatment with metformin, which is used clinically to activate AMPK , can lead to the upregulation of USP10 and, thus, PTEN-induced tumor suppression."
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"These results suggest that S76 phosphorylation of USP10 increases the deubiquitinase activity of USP10."
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"We speculate that kinase-mediated phosphorylation regulates the activity of USP10, allowing USP10 to regulate mitotic proteins independent of its expression.E3–DUB interactions allow fine-tuning of the ubiquitylation status of a common substrate, which generally involves a non-competitive binding mechanism (antagonistic pattern) [11, 22, 23, 40]."
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"Together, these results suggested that AMPK phosphorylates USP10 at S76, which activates USP10 and facilitates further activation of AMPK under energy stress, forming a feedforward loop."
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"Zhenkun Lou et al. have found that AMPKα1 or AMPKα2 ubiquitination blocks its phosphorylation by LKB1, which could be rescued by the deubiquitinase ubiquitin specific peptidase 10 (USP10) [54]."
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