IndraLab

Statements

USP10 activates USP10. 4 / 5
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"Together, these results suggested that AMPK phosphorylates USP10 at S76, which activates USP10 and facilitates further activation of AMPK under energy stress, forming a feedforward loop.Given the impo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Zhenkun Lou et al. have found that AMPKα1 or AMPKα2 ubiquitination blocks its phosphorylation by LKB1, which could be rescued by the deubiquitinase ubiquitin specific peptidase 10 (USP10) [54]."
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"These results suggest that S76 phosphorylation of USP10 increases the deubiquitinase activity of USP10."
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"Together, these results suggested that AMPK phosphorylates USP10 at S76, which activates USP10 and facilitates further activation of AMPK under energy stress, forming a feedforward loop."
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