IndraLab

Statements

PSMD14 activates Osteosarcoma. 9 / 9
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"This suggests that PSMD14 promotes osteosarcoma resistance to anlotinib in resistant sublines."
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"These results suggested that PSMD14 may considerably enhance the in vitro invasion and migratory capabilities of osteosarcoma cells."
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"CCK-8 assays demonstrated that the knockdown of PSMD14 significantly reduced osteosarcoma cell viability to around 50% of control shRNA-treated cells at 96 h (Fig. 2J, K)."
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"These results indicated that stable PSMD14 knockdown also greatly suppressed osteosarcoma development."
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"These findings imply that PSMD14 may increase osteosarcoma function by stimulating the PI3K/AKT/mTOR pathway."
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"In vitro, PSMD14 overexpression stimulated osteosarcoma cell proliferation."
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"Its function and mechanism in tumorigenesis and its potential significance in drug resistance remain unknown.In our work, we discovered that in vivo and in vitro overexpression of PSMD14 was adversely correlated with a poor prognosis in osteosarcoma; PSMD14 may induce malignant osteosarcoma characteristics by the PI3K/AKT/mTOR pathway, according to a preliminary study."
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"Knockdown of PSMD14 in osteosarcoma cells reduced the viability, proliferation, and invasion activities of osteosarcoma cells in vitro."
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"Transwell experiments revealed that knockdown of PSMD14 significantly inhibited the invasive ability of osteosarcoma cells."
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