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MDM2 increases the amount of MDM2. 79 / 89
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"We also found that Mdm2 indeed plays a causal role in the process, since simultaneous deletion of one Mdm2 allele to reduce Mdm2 levels rescued defective Atm activation."
29396424
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"To the contrary, MDM2 expression can be enhanced by activated p53 via induction of MDM2 promoter activity or by increased MDM2 protein stabilization."
27666947
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"As expected, the MDM2 vector induced MDM2 protein overexpression (XREF_FIG)."
23766666
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"A single nucleotide polymorphism (SNP) in the promoter region of MDM2, SNP T309G (rs2279744), has been identified and was demonstrated to up-regulate the expression of MDM2 via a greater affinity for the SP1 transcription factor."
24423195
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"As shown in XREF_FIG, the expression of MDM2 in A549 cells was upregulated to 1.5 times that in the negative control group (P = 0.003) after inhibitor-miR1273f transfection, and mimic-miR1273f transfection significantly downregulated the expression of MDM2 to 2/3 of that in negative control group (P = 0.035)."
33612481
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"A functional variant in the MDM2 gene promoter, single-nucleotide polymorphism 309 (SNP309) T> G (rs2279744), has been reported to cause an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity, which may be associated with the development of cancer."
24792886
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"Notably, ATM mutations and MDM2 polymorphisms causing aberrant MDM2 expression have been shown to harbor prognostic relevance in CLL [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19715592
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"Recent data suggested that MDM2 gene polymorphisms may contribute to increased MDM2 basal expression and increase cancer susceptibility."
27506496
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"Histone demethylase JMJD2C removed the H3K9me3 modification of MDM2 promoter, which promoted the expression of MDM2."
35468881
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"In 2004, Bond et al. reported that the GG genotype of MDM2 SNP309 can significantly increase the expression of MDM2 and thereby suppress the p53 pathway (12)."
21565629
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"It has previously been observed that InuA inhibits the protein expression of an MDM2 activator, NFAT1, which directly binds to the MDM2 P2 promoter via its DNA binding domain (DBD) and activates MDM2 transcription."
29311926
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"However, the damage induced alternative splicing of the MDM2 gene seems to be independent of its endogenous promoter, as the transcription of MDM2 minigenes are not driven by the endogenous MDM2 promo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19631207
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"A single nucleotide polymorphism (SNP) in the promoter region of MDM2, SNP T309G (rs2279744), has been identified and was demonstrated to up-regulate the expression of MDM2 via a greater affinity for the SP1 transcription factor."
24098760
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"For instance, MDM2 SNP309 (rs2279744, T> G) within promoter P2 enhances the affinity of promoter with the transcriptional activator SP1 to increase MDM2 transcription, thereby promoting tumor development in the different tissues."
28794641
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"Importantly, MDM2 forms a negative-feedback loop in regulating p53 activity, in which p53 induces transcription of MDM2, and, in turn, the MDM2 protein inhibits p53 activity [XREF_BIBR]."
21656578
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"The MDM2 SNP309 polymorphism increases the affinity of Sp1 for the MDM2 promoter and causes overexpression of MDM2."
23451111
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"Exogenous MDM2 expression in HCT116 p53 -/- cells downregulated levels of exogenously expressed SUV39H1 wt but not an MDM2 resistant SUV39H1 K87A mutant, confirming previous findings that lysine 87 is the site of ubiquitination by MDM2 (XREF_SUPPLEMENTARY)."
26971997
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"Recent studies have also shown that a single nucleotide polymorphism (SNP) in the MDM2 promoter (SNP309), which slightly increases MDM2 levels (by ~ 2-fold), significantly impacts upon tumorigenesis through attenuating p53 function in both human beings and animal models [XREF_BIBR, XREF_BIBR]."
26840028
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"The ubiquitin ligase MDM2 also ubiquitinates and causes the degradation of E-cadherin, and in human breast carcinoma specimens, increased MDM2 expression was associated with decreased E-cadherin protein levels."
22674073
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"A single nucleotide polymorphism (SNP309) of MDM2 causes elevated MDM2 levels and an attenuation of p53 function."
22134502
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"The importance of MDM2 in neuroblastoma pathogenesis is further illustrated by studies which have observed that a SNP within the MDM2 promoter (SNP309 T to G) that can lead to higher expression of MDM2 and greater inhibition of p53, is associated with poor survival in neuroblastoma, in particular stage 4 patients with MYCN amplification."
23226679
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"In human telomerase reverse transcriptase (hTERT)-immortalized human keratinocytes, exposure to low-dose arsenite inhibited p53 expression by transcriptionally upregulating murine double minute 2 (MDM2) or ERK2-mediated overexpression of MDM2 [172]."
32033297
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"There are a number of pre-clinical studies demonstrating the promise of targeting MDM2 via PPIs in cancers with either high endogenous MDM2 expression or targeting MDM2 following induction of MDM2 expression via DNA damaging agents [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29065514
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"A MDM2 SNP at the 309th nucleotide in the first intron (rs2279744), with a T to G change, could increase the affinity for stimulatory protein 1 binding and result in increased MDM2 expression and subsequent attenuation of the TP53 pathway."
29423041
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"Mouse double minute (MDM) 2 single nucleotide polymorphism (SNP) 309G allele in the second promoter of MDM2 enhances vitreous induced expression of Mdm2 and degradation of the tumor suppressor protein p53."
31278903
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"IRF8 binds to the MDM2 promoter inducing MDM2 expression."
28351930
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"Together, p53 and Mdm2 function in a negative feedback loop, with p53 driving the transcription of mdm2 during times of normal homeostasis and maintaining low levels of p53 protein."
21624367
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"A single-nucleotide polymorphism (SNP) in the promoter region of MDM2 (SNP309T> G, rs2279744) has been shown to increase the expression of the MDM2 protein in various cancer types."
28083704
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"Mdm2 transgenic mice, in which the Mdm2 transgene was driven from its normal promoter to create an approximately 4-fold elevation in Mdm2 expression, have an increased incidence of cancer, but not until later in life."
24488925
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"MDM2 is a negative regulator of TP53 and MDM2 SNP309 has been shown to increase MDM2 expression."
23034890
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"A T to G change of MDM2 SNP309 could increase the affinity of the transcriptional activator Sp1 with the promoter of MDM2, which could lead to an increased expression of MDM2 and a downregulation of the p53."
28885338
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"The Mdm2 promoter SNP309 was shown to increase Mdm2 expression and can, thereby, inhibit the p53 pathway."
18577987
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"An SNP in the MDM2 protein at location 309 from thymine to guanine enhances transcription of MDM2, reducing p53 mediated apoptosis."
29307398
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"One feedback loop is between p53 and the E3 ubiquitin ligase Mdm2, in which p53 activates Mdm2 expression and Mdm2 targets p53 for degradation."
21556066
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"There is a negative feedback loop between P53 and MDM2, in which activating p53 protein increases MDM2 transcription, and the resulting MDM2 protein interacts with p53, thereby causing p53 degradation."
28794641
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"A single nucleotide polymorphism (SNP309G) in the mdm2 promoter increases expression of Mdm2 XREF_BIBR."
19360021
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"The G-variant of the Mdm2 SNP309, which is located within the promoter of the Mdm2 gene, increases expression of Mdm2 and thereby inhibits the p53 pathway."
24217660
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"Because of the role of the E3 ubiquitin ligase, MDM2, in AR-Ub and that another KDM4 family member, KDM4C, has been described to enhance MDM2 levels, we questioned whether MDM2 levels were affected by KDM4B."
23435229
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"The current regulatory model of HDM2 and p53 consists of an auto-regulatory feedback loop; MDM2 transcription is induced by p53 and MDM2 binds to the transcriptional activation domain of p53, thereby [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21930127
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"P53 activates Mdm-2 transcription through binding to its promoter and up-regulates Mdm-2 expression."
24012397
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"In other words, the increase of p53 restored the decrease of MDM2 transcriptional activity caused by XBP1 suppression, resulting in the overall unchanged MDM2 mRNA expression level in XBP1 silenced HCT116 WT cells."
29057323
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"In conclusion, we have provided strong evidence that E/R abrogates p53 signaling through the direct induction of MDM2 expression, a cellular attribute that can be reversed in vitro by the inhibition of MDM2."
24240203
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"MI-43 induced the accumulation of p53 and its downstream target genes, Mdm2, p21, Noxa and Puma only in wt p53-containing cells, indicating that disruption of Mdm2-p53 binding increases p53"
18340116
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"MDM2-rs2279744 (also referred to as SNP309, T/G) is located in the first intron of the MDM2 promoter, which drives transcription of the MDM2 gene."
23218882
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"In solid tumours, MDM2 overexpression is caused by MDM2 gene amplification (Ladanyi et al, 1993)."
11953887
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"Research shows that wild-type p53 can combine with the promoter region of proto-oncogene murine double minute chromosomes 2 (MDM2) to enhance MDM2 protein expression."
29296226
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"Since p53 itself induces MDM2 transcription and expression, MDM2 functions as a negative-feedback inhibitor of p53.The effects of radiation and many chemotherapeutic agents are mediated via wild-type [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12804699
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"Therefore a mutation in the MDM2 gene promoter can enhance MDM2 expression and consequently reduce the tumor suppressor function of p53 [XREF_BIBR]."
27386018
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"TSLP (p < 0.05) and MDM2 levels were suppressed by cisplatin in serum or liver of septic mice (Figure 6D–F), indicating that cisplatin inhibits TSLP level through downregulation of MDM2 expression."
31480519
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"Interestingly, SHPK170R failed to inhibit Mdm2 ubiquitination (XREF_FIG), which correlated with its lack of effect to increase Mdm2 protein expression (XREF_FIG)."
22575647
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"We found that oroxylin A remarkably inhibited aerobic glycolysis in wt-p53 cancer cells and suppressed MDM2 mediated degradation of p53 through inhibiting SIRT3 modulated transcription of MDM2."
25902914
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"RPS27a knockdown increased the expression of MDM2 and p53 (Fig. 4E; comparison of lane 3 with lane 2 in lower panels), MDM2 ubiquitinated p53, whereas RPS27a knockdown inhibited this ubiquitination that led to p53 accumulation (Fig. 4E; comparison of lane 3 with lane 2 in upper panel)."
35073964
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"Previous work has shown that p53 * hDM2 antagonists stabilize p53 levels and induce expression of the p53 target genes hDM2 and p21."
19266537
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"The present study shows that the MDM2 SNP309G allele was not associated with increased MDM2 mRNA levels, in contrast to the MDM2 SNP285C allele, which significantly increased relative MDM2 mRNA expression."
28819417
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"A single-nucleotide polymorphism at position 309 (SNP309) in MDM2 promoter generates a binding site for the transcription factor SP1, increases MDM2 expression, and leads to mitigated p53 activity and acceleration of tumor development in humans (Bond et al., 2004)."
31310659
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"On the basis of examining 522 cases and 712 controls, our data showed that MDM2 309GG, which increase MDM2 expression level in NPC tissue, and TP53 72Pro/Pro genotypes were statistically significantly associated with increased risk of NPC."
20398418
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"T --> G single-nucleotide polymorphism at position 309 (SNP309) of mdm2 induces overexpression of mdm2, but inhibits p53."
16825434
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"RNA interference showed that p53 knockdown increased the protein level of Gli1 but decreased the level of MDM2, and enhanced cell invasion and migration in wild-type p53 Capan-2 cells; whereas Gli1 or MDM2 knockdown did not change p53 expression, but decreased the protein level of MDM2 or Gli1, respectively, and inhibited cell invasion and migration in mutant p53 PANC-1 cells."
24289472
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"The HDM2 SNP309 G/G (rs 2279744) polymorphism with raised promoter recognition by Sp1 transcription factor elevates HDM2 expression and attenuation of apoptosis mediated by TP53 [XREF_BIBR]."
27898708
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"It is totally unexpected that the protein level of both MDM2 and p53 is downregulated by MDM2 degraders based on ligands derived from Ugi reactions."
33862513
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"It has further been reported that p53 protein can bind to a regulatory element in the first intron of MDM-2, which allows enhanced expression of MDM-2 [24]."
7982210
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"When DNA is damaged, p53 binds to the P2 promoter of Mdm2, which leads to increased Mdm2 levels and subsequent decreased p53 levels."
28093454
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"The MDM2-rs2279744 and MDM2rs937283 variants are located in the MDM2 promoter, which initiates differential transcriptions of MDM2."
28045062
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"miR-194-5p transduction and the silencing of MDM2 decreased MDM2 expression and thereby increased p53 and p21 expression in p53 wild type HeyA8-TR cells [XREF_BIBR]."
30774764
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"It has also been reported that the GG type of MDM2 SNP309 can increase the MDM2 level and leads to attenuation of TP53 function."
30288482
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"For those tumors expressing wild-type p53, their p53 functions are always inhibited through several different mechanisms, one of which is the overexpression of MDM2 caused by the amplification of MDM2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30253242
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"The minor allele of MDM2 that includes a 309T> G transversion (single-nucleotide polymorphism rs2279744) in the MDM2 promoter is known to enhance MDM2 expression."
21051655
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"The 2 proteins are linked by an autoregulatory loop in which expression of Mdm2 is induced by p53 and Mdm2 in turn targets p53 for proteosomal degradation."
18558393
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"The presence MDM2 SNP309 G/G may lead to the overexpression of MDM2 and therefore cause downregulation of p53 in an effective manner and render mutational inactivation of p53 unnecessary."
19226467
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"The expression of endogenous MDM2 was significantly decreased by MDM2 shRNA, which in turn promoted AR expression (Fig. 7d), thus confirming that AR turnover mediated by SUMO3-modified PIAS1 was MDM2-dependent."
31752909
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"MDM2 Gene Amplification and Expression of MDM2 and CDK4 are Rare in Ossifying Fibroma of Craniofacial Bones."
35546651
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"Exogenous MDM2 expression in HCT116 p53 -/- cells downregulated levels of exogenously expressed SUV39H1 WT, but not an MDM2 resistant SUV39H1 K87A mutant, confirming previous findings (Bosch-Presegue [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26971997
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"The SNP in the MDM2 promoter (SNP309) results in the increased levels of MDM2 to promote tumorigenesis [XREF_BIBR, XREF_BIBR]."
26840028
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"The MDM2 SNP309 G/G homozygous genotype elevates MDM2 protein expression [XREF_BIBR]."
17537232
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"To understand its potential function in gliomagenesis, the authors analyzed a novel single nucleotide polymorphism (SNP) in the MDM2 promoter that enhances MDM2 expression."
18976073
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"As shown in Figures XREF_FIG, the transient transfection of MDM2 siRNA caused approximately 72% KD of MDM2 protein expression, decreased the cell growth, and strengthened the inhibitory effects of JapA on cell viability in MDA-MB-231 cells."
25739118
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"MDM2 SNP309 is a single nucleotide T to G polymorphism located in the MDM2 gene promoter, which enhances the expression of MDM2 protein and thereby leads to attenuation of the p53 stress response."
25361931
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"A MDM2 single nucleotide polymorphism at the 309 th nucleotide in the first intron (rs2279744), with a T to G change, could increase the affinity for stimulatory protein (Sp) 1 binding and result in increased MDM2 expression and subsequent attenuation of the P53 pathway XREF_BIBR."
22844496
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"In breast cancer, the potential prognostic significance of Mdm2 or an Mdm2 promoter polymorphism (SNP309) that enhances Mdm2 expression has been inconsistent."
21169420