IndraLab

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CYLD is degraded. 4 / 4
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"Meanwhile, miR-301b-3p can suppress CYLD expression in HCC cells, consequently leads to hyperactive NF-κB signaling, higher level of CXCL5 secretion, and more TANs recruitment, forming a positive feedback loop [57]."
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"This decrease of caspase-8 levels in ELAVL1 KO cells did not result from a compromise of IFNγ signaling, as (i) KO expression of ELAVL1 decreased basal caspase-8 expression in the absence of IFNγ stimulation; and (ii) ELAVL1 KO did not block IFNγ-stimulated IRF1 and the downstream CYLD expression (Fig. 7 K and Fig. S5 B)."
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"A previous study found that Notch stimulates NF-κB activation by initiating the transcription of Hes1, which then suppresses the expression of CYLD, a negative regulator of IKK activity in T-ALL cells [23]; however, this finding does not rule out the possibility that other mechanisms co-exist."
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"Thus, the present study revealed that, in bladder cancer, NF-kappaB can maintain its activity by establishing a feedback loop, in which NF-kappaB induced the expression of miR-130b, which consequently inhibited the expression of CYLD, which in turn was an endogenous inhibitor of NF-kappaB activation."
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