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Verruculogen inhibits KCNMA1. 2 / 2
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"Our structure and MD simulations revealed that Compound 23 may inhibit Slo2.2 by restricting the access of hydrated K + to the SF ( Figure 7 C), a similar mechanism by which verruculogen inhibits Dm _[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly, in CHO cells expressing Dm Slo the voltage activated K + currents elicited in the presence of 290 nM free intracellular Ca 2+ were completely blocked by the BK channel antagonist verruculogen at 3 muM (XREF_FIG; n = 5) and the dose response curve revealed an IC 50 value of 6.2 nM for inhibition of Dm Slo by verruculogen (95% confidence intervals 2.52 to 8.57 nM) and an IC 50 value of 0.5 nM for inhibition of Dm Slo by penitrem A (95% confidence intervals 0.43 t0 12.9 nM; XREF_FIG)."
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