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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

Verruculogen inhibits KCNMA1. 1 / 1

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"Similarly, in CHO cells expressing Dm Slo the voltage activated K + currents elicited in the presence of 290 nM free intracellular Ca 2+ were completely blocked by the BK channel antagonist verruculogen at 3 muM (XREF_FIG; n = 5) and the dose response curve revealed an IC 50 value of 6.2 nM for inhibition of Dm Slo by verruculogen (95% confidence intervals 2.52 to 8.57 nM) and an IC 50 value of 0.5 nM for inhibition of Dm Slo by penitrem A (95% confidence intervals 0.43 t0 12.9 nM; XREF_FIG)."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...