IndraLab

Statements

Salicylate inhibits IKBKB. 11 / 11
| 11
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"In the present study, we wished to test the hypothesis that sodium salicylate, which inhibits IKKbeta , prevents hepatic insulin resistance caused by short-term elevation of FFA."
17951543
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"Insulin resistance was improved by systemic neutralization of IL-6 or salicylate inhibition of IKK-beta."
15685173
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"Salicylate inhibits IKKβ, to prevent the deleterious effects of excess FFA on insulin signaling and action [ xref , xref ]."
27128935
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"IKKB is inhibited by salicylates, such as aspirin and sodium salicylate (SS; xref )."
23328071
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"Accordingly, abrogation of inflammatory signaling with salicylates, which inhibit IKKβ, prevents inhibitory IRS-1 phosphorylation, restoring insulin sensitivity ()."
25035952
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"To support this finding, inhibition of IKKβ by salicylate was effective in ameliorating inflammation-mediated insulin resistance (Yuan et al., xref )."
23761785
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"Aspirin, salicylate, and sulindac can directly bind and inhibit recombinant IKKβ, the upstream positive regulator of NF-κB ( xref )."
23875171
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"Lastly, direct inhibition of IKKβ by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-κB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."
23875171
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"Salicylate inhibits IKK beta in concentrations that are achievable with dose schedules traditionally used in treating rheumatoid arthritis (3-4.5 g daily); indeed, this is likely to be the mechanism responsible for salicylate's utility in this disorder."
20080359
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"The importance of NF-κB in the induction of insulin resistance is apparent in the improvements in insulin sensitivity resulting from inhibition of IKKβ by high dose salicylate [ xref ]."
19922415
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"Because salicylates inhibit IKKβ [55,56] , Shoelson proposed that the hypoglycemic effects of these compounds might be due to inhibition of the NF-κB system."
12393301