IndraLab

Statements

STAMBP activates ERK. 9 / 9
| 1 8
sparser
"The characterization of the second clone involved the study of ERK1/2 activation by α-MSH in order to guarantee that observations were not clone specific."
22871966
sparser
"Since MC5R activation was reported to promote binding of β-arrestin 2 ( Cai et al., 2006 ), we tested whether β-arrestins 1/2 are involved in α-MSH-induced ERK1/2 activation."
22871966
sparser
"In GT1-7 cells, ERK1/2 activation through MC4R induced by α-MSH is only PKA-dependent [ xref ]."
28433713
sparser
"We found that α-MSH induced significant activation of ERK1/2 in the WT hMC3R (Fig. xref ), consistent with previous studies when the WT MC3R was stimulated with either NDP-MSH or D-Trp 8 -γ-MSH as well as in mouse dorsal medial nucleus and ventromedial nucleus xref , xref , xref , although not consistent with another report xref ."
25798062
sparser
"In pEGFPN1-transfected cells, α-MSH did not activate ERK1/2 (A, lanes GFP)."
19428994
sparser
"For instance, our results demonstrate that the late activation of ERK1/2 by α-MSH is also β-arrestins dependent."
22871966
sparser
"Tyrosinase (TYR) is a key enzyme that regulates melanin synthesis, xref which is regulated by a microphthalmia-associated transcription factor (MITF). xref It is reported that Erk1/2 activation can phosphorylate MITF at Ser73 and 409 sites, leading to a temporary increase in the trans-activation activity and subsequent degradation of MITF. xref As α-MSH can activate the ERK1/2 signaling via binding to MC1R, xref , xref we conjecture that ERK1/2/MITF/TYR signaling may be involved in α-MSH-PE38KDEL-mediated apoptosis of melanoma cells."
33299329
reach
"Small molecule inhibitors of EGFR and MAPK signaling pathway may block STAMBP induced cell mobility and invasion as well as ERK activation in cells."
34102455
sparser
"As shown in A, the inhibition of adenylyl cyclase has no effect on α-MSH-induced ERK1/2 activation."
19428994