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Silibinin decreases the amount of USP18. 1 / 1
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"Using multiple inhibitors of TNF-α/LPS signaling, we found that two inhibitors, silibinin (an inhibitor of IKKα) and NSC33994 (a Jak2 inhibitor) possess the ability to inhibit TNF-α and LPS-induced USP18 expression and proinflammatory effects."