IndraLab

Statements

CTNNB1 phosphorylated on S33 decreases the amount of CTNNB1. 4 / 4
3 1 |
bel
"beta-Catenin phosphorylation at serine 45 (Ser45), threonine 41 (Thr41), Ser37, and Ser33 is critical for beta-catenin degradation, and regulation of beta-catenin phosphorylation is a central part of the canonical Wnt signaling pathway."
16618120
bel
"Serine-33 and -37 of beta-catenin are GSK3 phosphorylation sites that serve as recognition sites for the beta-TRCP-ubiquitin ligase complex, which ultimately triggers beta-catenin degradation."
12417018
bel
"It is known that Ser33, Ser37, and Thr41 are phosphorylated by GSK3β, which creates the binding site for β-TrCP and subsequent ubiquitination by the E3 ubiquitin ligase system.[6,7]"
25546293
bel
"cyclin-CDK2 demonstrate beta-catenin phosphorylation on residues Ser(33), Ser(37), Thr(41), and Ser(45). This phosphorylation promotes rapid degradation of cytosolic beta-catenin"
14985333