IndraLab

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USP13 inhibits USP10. 2 / 2
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"It will be interesting to elucidate if the stability of the other PI3K and III complex members is also affected, as in the case of Spautin-1 -- mediated inhibition of USP10 and USP13 [XREF_BIBR] and if the control of Beclin 1 stability is mediated by HSP90 in general or whether this represents a regulatory event specifically developed in phagocytic cells."

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"USP13 further modulates this network by regulating USP10 degradation, as demonstrated in the heart, lung and liver of newborn mice [104]."