IndraLab
Statements
reach
"Like many of the candidates identified in our initial genome-wide screen, Usp47 RNAi was found to cause a decrease in MAPK protein levels (XREF_FIG) [XREF_BIBR], whereas it did not visibly alter the expression levels of JNK (FBgn0000229) and p38b (FBgn0024846), two other members of the MAPK family, nor of other RAS-MAPK pathway proteins (XREF_FIG)."
reach
"However, as Usp47 RNAi only partially depletes MAPK levels compared to the effect of mapk dsRNA itself (XREF_FIG), it might be expected that another DUB is acting redundantly to protect MAPK from complete degradation, in which case this factor should display an aggravating genetic interaction with Usp47 RNAi (XREF_SUPPLEMENTARY)."