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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP47 decreases the amount of MAPK. 2 / 2

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"Like many of the candidates identified in our initial genome-wide screen, Usp47 RNAi was found to cause a decrease in MAPK protein levels (XREF_FIG) [XREF_BIBR], whereas it did not visibly alter the expression levels of JNK (FBgn0000229) and p38b (FBgn0024846), two other members of the MAPK family, nor of other RAS-MAPK pathway proteins (XREF_FIG)."

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"However, as Usp47 RNAi only partially depletes MAPK levels compared to the effect of mapk dsRNA itself (XREF_FIG), it might be expected that another DUB is acting redundantly to protect MAPK from complete degradation, in which case this factor should display an aggravating genetic interaction with Usp47 RNAi (XREF_SUPPLEMENTARY)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...