IndraLab

Statements

SETD7 methylates TP53 on lysine. 8 / 8
| 7 1
sparser
"C-terminal lysine residues of p53 are methylated in vivo at K370, K372, K373, and K382 by histone lysine methyl transferases, Smyd2, SET9, G9a/Glp, and Set8, respectively. xref – xref While K372 methylation by SET9 in human cells enhanced p53 transcriptional activities, the role of p53 methylation in the mouse by Set7/9 was controversial. xref – xref However, it should be pointed out that the results from mouse embryonic fibroblasts in the mouse study might be inappropriate to apply to human epithelial cells."
27270439
reach
"Indeed, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) methylate p53 at specific C-terminal lysines."
18581285
reach
"Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases : transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9."
18260647
reach
"For instance, lysine methylation of p53 by the SETD7 and the nuclear factor κB by the methyl transferase nuclear receptor-binding SET domain-containing protein 1 distinctly increase their ability to bind the promoter and activation of downstream genes [156, 158]."
30344952
reach
"We provide the first genetic evidence demonstrating that lysine methylation of p53 by Set7/9 is important for p53 activation in vivo and suggest a mechanistic link between methylation and acetylation of p53 through Tip60."
18280244
reach
"QPCR analysis also showed that Mll2 Gdf9 cKO oocytes overexpressed several apoptosis associated genes (XREF_TABLE), including p53 (transformation related protein 53; TRP53) and Setd7 (SET domain lysine methyltransferase 7, also know as Set7/9) (XREF_TABLE and XREF_SUPPLEMENTARY), which methylates p53 and prevents its degradation XREF_BIBR."
20808952
reach
"In 2004, Chuikov et al. found that K372 of p53 is mono-methylated by Set7/9 lysine methyltransferase [49]."
17306845
reach
"Originally defined as a critical layer of p53 regulation in human cell lines, p53 lysine methylation by Set7/9 (also called Setd7) was proposed to fulfill a similar function invivo in the mouse, promoting p53 acetylation, stabilization, and activation upon DNA damage (Kurash etal., 2008)."
21855806