IndraLab

Statements

ZUP1 inhibits FBXW7. 2 / 2
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reach
"In this review, we focus on discussing the specific roles of USP28 in cancer pathways, and their potential therapeutic values in cancer treatment.USP28 was the first FBW7-antagonizing DUB in an shRNA screen using c-MYC stability as a readout in human tumor cells16."
29415985
reach
"Below, we will review the mechanisms accounting for the involvement of USP28 in these pathways (Fig 3, Table 1 ), hence demonstrating its significance as a therapeutic target for cancer treatment.Disrupting physiological homeostasis of ubiquitination process USP28 was the first FBW7-antagonizing DUB in an shRNA screen using c-MYC stability as a readout in human tumor cells 16 ."
29415985