IndraLab
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"Pro-HB-EGF is cleaved at the cell surface to yield the soluble form of HB-EGF (sHB-EGF). xref Subsequently, sHB-EGF directly binds to both EGF receptor (EGFR) and ErbB4, xref which triggers receptor dimerization and activates downstream kinases, including extracellular signal-regulated kinase (ERK), JNK, and phosphatidylinositol 3-kinase (PI3K). xref It has been reported that osteoblast differentiation and bone formation can be regulated by EGFR signaling."