A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

SHB binds EGF and EGFR. 4 / 4
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"Because Y-142 and CRM197 bind to HB-EGF and cetuximab binds to EGFR, it is difficult to directly compare the amino acids used for binding by each reagent to inhibit the sHB-EGF-EGFR interaction."
"This data suggested that sHB-EGF interacts with EGFR during its translocation to the nuclear envelope."
"EGFR is one of the HB-EGF receptors, and the binding of sHB-EGF to EGFR leads to phosphorylation of EGFR and activation of its downstream signaling."
"Pro-HB-EGF is cleaved at the cell surface to yield the soluble form of HB-EGF (sHB-EGF). xref Subsequently, sHB-EGF directly binds to both EGF receptor (EGFR) and ErbB4, xref which triggers receptor dimerization and activates downstream kinases, including extracellular signal-regulated kinase (ERK), JNK, and phosphatidylinositol 3-kinase (PI3K). xref It has been reported that osteoblast differentiation and bone formation can be regulated by EGFR signaling."