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Statements

PSMD14 activates SNAI1. 7 / 7
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"In esophageal squamous cell carcinoma, knockdown of PSMD14 significantly blocks SNAIL-induced epithelial mesenchymal transition (EMT), thus suppressing tumor cell migration and metastasis (Zhu et al., 2018)."
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"These findings suggest that PSMD14 could obviously induce EMT process through stabilizing SNAIL.Since SNAIL is reported to be involved in tumorigenesis and metastasis through EMT process [ 6–9 ], we p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It seems to be a promising cure for metastatic tumor to develop small molecule inhibitors for PSMD14 to target PSMD14-induced SNAIL accumulation and EMT process."
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"PSMD14 increases the stability of the Snail protein, a transcription factor associated with epithelial-mesenchymal transition (EMT), thus inducing metastasis in esophageal cancer cells [41]."
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"Taken together, in this study, PSMD14 is characterized as an oncogenic protein to enhance tumor metastasis by regulating SNAIL stability in esophageal squamous cell carcinoma.Several studies proved th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, OTUB1 (an OTU family protein) and PSMD14 (a JAMM family protein) promotes metastasis of human esophageal squamous carcinoma by stabilizing Snail [21,22]."
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"The knockout of PSMD14 has been shown to markedly decrease the expression of the epithelial–mesenchymal transition related transcription factors SLUG and SNAIL, potentially elucidating the association between PSMD and lymph node metastasis [36,37]."
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