IndraLab

Statements

MTOR phosphorylated on S2448 is kinase-active. 4 / 4
2 2 |
bel
"We first studied the effect of 12 h exposure to T3 on S2448 phosphorylation of mTOR to match the exposure time for Northern blot analysis (Fig. 1A). As shown in Fig. 1B, an increase in S2448 phosphorylation was detected after 12 h exposure to T3....The phosphorylation is associated with a marked increase in T389 phosphorylation of p70S6K. These results demonstrate T3-dependent phosphorylation of S2448 activates mTOR kinase."
15388791
bel
"In contrast to the effect of phosphorylation by Akt/PKB on most of its substrates, phosphorylation of mTOR on Ser2448 reportedly promotes mTOR-dependent signalling (Nave et al. 1999)."
15294054
bel
"In contrast to the effect of phosphorylation by Akt/PKB on most of its substrates, phosphorylation of mTOR on Ser2448 reportedly promotes mTOR-dependent signalling (Nave et al. 1999)."
15294054
bel
"We first studied the effect of 12 h exposure to T3 on S2448 phosphorylation of mTOR to match the exposure time for Northern blot analysis (Fig. 1A). As shown in Fig. 1B, an increase in S2448 phosphorylation was detected after 12 h exposure to T3....The phosphorylation is associated with a marked increase in T389 phosphorylation of p70S6K. These results demonstrate T3-dependent phosphorylation of S2448 activates mTOR kinase."
15388791