IndraLab
Statements
Magnesium atom activates KCNMA1. 19 / 19
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19
reach
"Additional support for a secondary site are the observations of Solaro et al. 1995 that cytoplasmic Mg 2+ modulates Ca 2+ -dependent activation of mSlo1 by binding to a low affinity site on the channel core, and the observations of Shi and Cui 2001 that Mg 2+ can increase BK channel activity under experimental conditions (1 mM Ca 2+ i), where the primary Ca 2+ binding sites would be saturated with Ca 2+ (Rothberg and Magleby 1999)."
reach
"If we assume that high concentrations of Ca 2+ and Mg 2+ bind to the same or similar sites and are able to promote activation of Slo1 currents in a similar fashion, then the results in XREF_FIG A can be used to " subtract " the effect of Ca 2+ at the putative low affinity site from the V 0.5 -pCa relationship shown in XREF_FIG E."