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Statements

EGFR phosphorylates itself on tyrosine. 38 / 38
| 1 37
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"Upon ligand binding, EGFR dimerisation undergoes autophosphorylation on multiple tyrosine (Y) residues within the cytoplasmic domain of EGFR, such as EGFR-Y992, -Y1045, -Y1068, and -Y1173."
27387133
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"The binding of EGF to its receptor induces dimerization of receptor subunits and stimulation of the tyrosine kinase activity of EGFR, and results in autophosphorylation of EGFR on specific tyrosine residues."
18594017
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"Ligand-bound EGFR autophosphorylates its cytoplasmic tyrosine residue, which can serve as a docking site for proteins like STAT3 that possess Src Homology 2 (SH2) domain [ xref ]."
30400136
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"In A431 cells, the EGF receptor autophosphorylates tyrosine residues and allows the recruitment of PLC-γ1 through interactions with the SH2 domains present on PLCγ1."
9247120
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"Upon activation by its growth factor ligands, EGFR autophosphorylates at several tyrosine residues."
25390346
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"This results in EGFR autophosphorylation in several tyrosine (Y) residues, including Y992, Y1045, Y1068, Y1148 and Y1173 xref ."
28892308
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"The autophosphorylation of the EGF receptor on multiple tyrosine residues is the critical step initiating the propagation of the signal inside the cell ( Hunter, 2000; Pawson and Nash, 2003; Schlessin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17081983
sparser
"The anti-invasive effect of oxidized streptolysin O on MDA-MB231 breast cancer cells is characterized by its ability to activate the autophosphorylation of EGFR selectively on tyrosine residues besides Y845, indicating that, in this case, Y845 may not be involved in the anti-cancer malignancy [ xref ]."
23702846
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"The autophosphorylation of EGFR at tyrosine residues in human hepatocellular carcinoma HepG2 cells (ATCC, Rockville, MD, USA) was determined by the method of Yang et al. [17] ."
11755203
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"EGFR undergoes autophosphorylation on five high affinity tyrosine residues localized to the C-terminus of the receptor."
7926042
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"Upon ligand binding, EGFR undergoes autophosphorylation at several tyrosine residues within its intracellular domain and triggers various signaling pathways including ERK."
21286276
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"Spontaneous ligand-independent EGFR autophosphorylation on tyrosine residues was inhibited by the EGFR specific inhibitor Pelitinib, which confirmed its enzyme activity ( xref )."
27223425
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"EGFR undergoes auto-phosphorylation at tyrosine residues and is reported to be involved in activating various downstream effectors of different signaling axis particularly, Ras/Raf/Mek/Erk and PI3K/Akt."
25493075
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"This process is accompanied by the decrease in the level of EGF receptor autophosphorylation at tyrosine residues."
1873350
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"The autophosphorylation of EGF receptor on tyrosine residues was also increased with increasing EGF concentration in cultured cells which were incubated 102 E.-B. Yuag et al. /J. Biochern."
8796482
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"After administration of soluble EGF, ligand-activated EGFR is usually autophosphorylated at multiple tyrosine (Tyr) residues, which among others include Tyr992, Tyr1068, Tyr1086, Tyr1148, and Tyr1173 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26079101
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"Gefitinib induced more remarkably decrease in EGFR autophosphorylation at Tyr residues 1173, 845, and 1045 in del746–750 cells, compared with the autophosphorylation levels in L858R cells, whereas aut[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18407408
sparser
"This confirms established literature on EGF stimulation by which EGFR is rapidly auto-phosphorylated on its cytoplasmic tyrosine residues triggering the recruitment of adaptor proteins such as GRB2 xref , SHC1 xref , and CBL xref , transducers of downstream signaling."
34876567
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"However, decreased levels of ganglioside expression were associated with 1) increased EGF receptor autophosphorylation on tyrosine residues, and 2) increased EGF-stimulated cellular proliferation."
2142159
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"It was shown in the other systems that upon binding of EGF to the extracellular domain the EGFR undergoes autophosphorylation on tyrosine residues."
10432234
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"After ligand binding, EGFR is mostly autophosphorylated in different tyrosine residues of the intracellular domain."
33273921
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"The autophosphorylation of the EGFR at tyrosine residues activates downstream signaling, such as the Ras-Raf-MEK-p44/p42 mitogen-activated protein (MAP) kinase pathway or phosphotidylinositol-3 kinase (PI3K)-Akt pathway, thus resulting in the activation of cell proliferation [ xref ]."
21722395
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"In this study, therefore, we employed these cells to investigate whether autophosphorylation of EGFR at specific tyrosine residues is required for EGF-induced membrane ruffle formation."
12586341
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"On ligand binding, EGFR dimerizes with neighboring receptors and is auto-phosphorylated at three major tyrosine residues [ xref ]."
25199985
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"However, gefitinib induced a more marked decrease in EGFR autophosphorylation at tyrosine residues 1173, 845, and 1045 and a lesser decrease at Y992 in del746–750 cells, compared with the autophosphorylation levels in L858R cells."
28352061
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"Through combining with its ligands, the EGFR takes shape dimers with other EGFR or other HER family members and experiences autophosphorylation at the crucial tyrosine residues, leading to activation of some downstream signalling pathways, which mediates a variety of cellular processes, including proliferation, survival and apoptosis."
29088904
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"These compounds are small ATP mimetics that inhibit autophosphorylation of EGFR at its cytoplasmic tyrosine residues by binding to the catalytic site."
25573954
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"After binding to its agonists EGF or transforming growth factor α (TGFα), EGFR forms homodimers and auto-phosphorylates several key intracellular tyrosine residues."
28121014
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"This leads to autophosphorylation of HERs in cytoplasmic tyrosine residues, which permits the docking of proteins involved in signal transduction [8–11] ."
20026098
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"Autophosphorylation of EGFR on specific tyrosine residues activates PI3K/AKT, Ras/MAPK, and JAK/STAT signaling pathways that lead to cancer cell survival [ xref ]."
27256981
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"Ligand-activated EGFR undergoes autophosphorylation on multiple tyrosine residues, most of which are located in the C -terminal non-catalytic sequence; they include Y992, Y1068, Y1086, Y1148, and Y1173 [ xref , xref – xref ]."
23702846
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"Autophosphorylation of EGFR at tyrosine residue could be detected by performing a kinase assay followed by immunoblotting."
27684475
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"Autophosphorylation of the EGF receptor on tyrosine residues and phospholipase Cyl signalling is involved with consequent Ça24' mobil- isation."
7520009
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"EGFR is auto-phosphorylated at tyrosine residues when it binds to its ligands, including EGF and transforming growth factor-α."
27382309
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"The EGF receptor autophosphorylates at five known tyrosine residues after the addition of EGF."
10459005
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"Expression of the mutant protein correlated with the detection of EGFR autophosphorylation at an important tyrosine residue (Y1092) ( xref ) ."
17726540
trips
"Based on these results, we conclude that TPA-induced AP-1 activation requires the basal level-EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation."
12527890
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"Upon activation by the binding of specific ligands, the autophosphorylation of the EGFR at several tyrosine residues initiates downstream signal transduction cascades, principally of the mitogen-activated protein kinase, Akt and c-Jun N-terminal kinase pathways."
26503469